Enteroendocrine Cells Support Intestinal Stem-Cell-Mediated Homeostasis in Drosophila
Ip, Y. Tony
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CitationAmcheslavsky, Alla, Wei Song, Qi Li, Yingchao Nie, Ivan Bragatto, Dominique Ferrandon, Norbert Perrimon et al. "Enteroendocrine Cells Support Intestinal Stem-Cell-Mediated Homeostasis in Drosophila." Cell Reports 9, no. 1 (2014): 32-39. DOI: 10.1016/j.celrep.2014.08.052
AbstractIntestinal stem cells in the adult Drosophila midgut are regulated by growth factors produced from the surrounding niche cells including enterocytes and visceral muscle. The role of the other major cell type, the secretory enteroendocrine cells, in regulating intestinal stem cells remains unclear. We show here that newly eclosed scute loss of function mutant flies are completely devoid of enteroendocrine cells. These enteroendocrine cell-less flies have normal ingestion and fecundity but shorter life span. Moreover, in these newly eclosed mutant flies, the diet-stimulated midgut growth that depends on the insulin-like peptide 3 expression in the surrounding muscle is defective. The depletion of Tachykinin producing enteroendocrine cells or knockdown of Tachykinin leads to a similar although less severe phenotype. These results together establish that enteroendocrine cells serve as an important link between diet and visceral muscle expression of an insulin-like growth factor to stimulate intestinal stem cell proliferation and tissue growth.
Citable link to this pagehttps://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37372480
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