Drosophila Jun Relays the Jun Amino-Terminal Kinase Signal Transduction Pathway to the Decapentaplegic Signal Transduction Pathway in Regulating Epithelial Cell Sheet Movement
Hou, Steven X.
Goldstein, Elliott S.
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CitationHou, Steven X., Elliott S. Goldstein, Norbert Perrimon. "Drosophila Jun Relays the Jun Amino-Terminal Kinase Signal Transduction Pathway to the Decapentaplegic Signal Transduction Pathway in Regulating Epithelial Cell Sheet Movement." Genes & Development 11, no. 13 (1997): 1728-1737. DOI: 10.1101/gad.11.13.1728
AbstractWe have characterized mutations in the Drosophila homolog of the mammalian proto-oncogene c-Jun gene (Djun). We demonstrate that DJUN in the embryo is a downstream target of the JNK signal transduction pathway during dorsal closure formation, and that the function of the JNK/DJUN pathway is to control the localized expression of decapentalegic (dpp), a member of the TGF-beta growth factor family. In contrast to previous observations, we find that both in the embryo and during photoreceptor cell determination, DJUN is not regulated by a pathway that involves MAPK.
Citable link to this pagehttps://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37372607
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