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dc.contributor.authorXu, Guofan
dc.contributor.authorRowley, Howard A.
dc.contributor.authorWu, Gaohong
dc.contributor.authorAlsop, David
dc.contributor.authorShankaranarayanan, Ajit
dc.contributor.authorDowling, Maritza
dc.contributor.authorChristian, Bradley T.
dc.contributor.authorOakes, Terrence R.
dc.contributor.authorJohnson, Sterling C.
dc.date.accessioned2022-07-15T16:45:57Z
dc.date.issued2010-04
dc.identifier.citationXu, Guofan, Howard A. Rowley, Gaohong Wu, David Alsop, Ajit Shankaranarayanan, Maritza Dowling, Bradley T. Christian et al. "Reliability and Precision of Pseudo-Continuous Arterial Spin Labeling Perfusion MRI on 3.0 T and Comparison With 15O-Water PET in Elderly Subjects at Risk for Alzheimer's Disease." NMR in Biomedicine 23, no. 3 (2010): 286-293. DOI: 10.1002/nbm.1462
dc.identifier.issn0952-3480en_US
dc.identifier.issn1099-1492en_US
dc.identifier.urihttps://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37372643*
dc.description.abstractArterial spin labeling (ASL) offers MRI measurement of cerebral blood flow (CBF) in vivo, and may offer clinical diagnostic utility in populations such as those with early Alzheimer's disease (AD). In the current study, we investigated the reliability and precision of a pseudo-continuous ASL (pcASL) sequence that was performed two or three times within one hour on eight young normal control subjects, and 14 elderly subjects including 11 with normal cognition, one with AD and two with Mild Cognitive Impairment (MCI). Six of these elderly subjects including one AD, two MCIs and three controls also received (15)O-water positron emission tomography (PET) scans 2 h before their pcASL MR scan. The instrumental reliability of pcASL was evaluated with the intraclass correlation coefficient (ICC). The ICCs were greater than 0.90 in pcASL global perfusion measurements for both the young and the elderly groups. The cross-modality perfusion imaging comparison yielded very good global and regional agreement in global gray matter and the posterior cingulate cortex. Significant negative correlation was found between age and the gray/white matter perfusion ratio (r = -0.62, p < 0.002). The AD and MCI patients showed the lowest gray/white matter perfusion ratio among all the subjects. The data suggest that pcASL provides a reliable whole brain CBF measurement in young and elderly adults whose results converge with those obtained with the traditional (15)O-water PET perfusion imaging method. pcASL perfusion MRI offers an alternative method for non-invasive in vivo examination of early pathophysiological changes in AD.en_US
dc.language.isoen_USen_US
dc.publisherWileyen_US
dc.relation.isversionofdoi:10.1002/nbm.1462en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843795/en_US
dash.licenseLAA
dc.subjectResearch Subject Categories::MEDICINE::Dermatology and venerology,clinical genetics, internal medicine::Internal medicine::Molecular medicine (genetics and pathology)en_US
dc.subjectResearch Subject Categories::MEDICINE::Physiology and pharmacology::Radiological research::Radiologyen_US
dc.titleReliability and Precision of Pseudo-Continuous Arterial Spin Labeling Perfusion MRI on 3.0 T and Comparison With 15O-Water PET in Elderly Subjects at Risk for Alzheimer's Diseaseen_US
dc.title.alternativeRELIABILITY AND PRECISION OF PSEUDO-CONTINUOUS ASL PERFUSION MRI
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalNMR in Biomedicineen_US
dash.depositing.authorAlsop, David
dc.date.available2022-07-15T16:45:57Z
dc.identifier.doi10.1002/nbm.1462
dc.source.journalNMR Biomed.
dash.source.volume23en_US
dash.source.page286-293en_US
dash.source.issue3en_US
dash.contributor.affiliatedAlsop, David


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