A Reference Map of the Human Binary Protein Interactome
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Kim, Dae-Kyum
Begg, Bridget E
Bian, Wenting
Campos-Laborie, Francisco J.
Choi, Dongsic
Coté, Atina
Deimling, Steven
Desbuleux, Alice
Dricot, Amélie
Gebbia, Marinella
Hardy, Madeleine
Kishore, Nishka
Knapp, Jennifer
Kovács, István A.
Lemmens, Irma
Mee, Miles W.
Mellor, Joseph C.
Pollis, Carl
Pons, Carles
Teeking, Bridget
Babor, Mariana
Basha, Omer
Chin, Suet-Feung
Colabella, Claudia
Coppin, Georges
D'Amata, Cassandra
De Rouck, Steffi
Duran-Frigola, Miquel
Ennajdaoui, Hanane
Goebels, Florian
Goehring, Liana
Gopal, Anjali
Helmy, Mohamed
Kassa, Yoseph
Landini, Serena
Li, Roujia
van Lieshout, Natascha
MacWilliams, Andrew
Rangarajan, Sudharshan
Rasla, John
Rayhan, Ashyad
Sheykhkarimli, Dayag
Simonovsky, Eyal
Taşan, Murat
Tropepe, Vincent
Twizere, Jean-Claude
Weatheritt, Robert
Weile, Jochen
Yeger-Lotem, Esti
Aloy, Patrick
Bader, Gary D.
De Las Rivas, Javier
Hao, Tong
Rak, Janusz
Tavernier, Jan
Roth, Frederick P.
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https://doi.org/10.1038/s41586-020-2188-xMetadata
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Luck, Katja, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E Begg, Wenting Bian, Ruth Brignall, et al. 2020. “A Reference Map of the Human Binary Protein Interactome.” Nature 580 (7803): 402–8.Abstract
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships. Here, we present a human “all-by-all” reference interactome map of human binary protein interactions, or “HuRI”. With ~53,000 high-quality protein-protein interactions (PPIs), HuRI has approximately four times more such interactions than high-quality curated interactions from small-scale studies. Integrating HuRI with genome, transcriptome, and proteome data enables the study of cellular function within most physiological or pathological cellular contexts. We demonstrate the utility of HuRI in identifying specific subcellular roles of PPIs. Inferred tissue-specific networks reveal general principles for the formation of cellular context-specific functions and elucidate potential molecular mechanisms underlying tissue-specific phenotypes of Mendelian diseases. HuRI represents a systematic proteome-wide reference linking genomic variation to phenotypic outcomes.Citable link to this page
https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37373073
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