DMSO Increases Radioiodination Yield of Radiopharmaceuticals
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CitationWang, Ketai, S. James Adelstein, and Amin I. Kassis. 2008. “DMSO Increases Radioiodination Yield of Radiopharmaceuticals.” Applied Radiation and Isotopes 66 (1): 50–59. https://doi.org/10.1016/j.apradiso.2007.07.026.
AbstractA high-yield radioiodination method for various types of molecules is described. The approach employs DMSO as precursor solvent, a reaction ratio of 2-5 precursor molecules per iodine atom, 5-10 mu g oxidant, and a 10-25 mu l reaction volume. The solution is vortexed at room temperature for 1-5 min and progress of the reaction is assessed by HPLC. Radioiodinated products are obtained in >= 95% yield and meet the requirements for radiotracer imaging, biodistribution studies, and molecular and cellular biology research.
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