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dc.contributor.authorHuang, Ying-Ying
dc.contributor.authorVecchio, Daniela
dc.contributor.authorAvci, Pinar
dc.contributor.authorYin, Rui
dc.contributor.authorGarcia-Diaz, Maria
dc.contributor.authorHamblin, Michael
dc.date.accessioned2018-12-18T15:56:39Z
dc.date.issued2013-01-01
dc.identifier.citationHuang, Ying-Ying, Daniela Vecchio, Pinar Avci, Rui Yin, Maria Garcia-Diaz, and Michael R. Hamblin. 2013. “Melanoma Resistance to Photodynamic Therapy: New Insights.” Biological Chemistry 394 (2). https://doi.org/10.1515/hsz-2012-0228.en_US
dc.identifier.issn1437-4315en_US
dc.identifier.issn1431-6730en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:37933094*
dc.description.abstractMelanoma is the most dangerous form of skin cancer, with a steeply rising incidence and a poor prognosis in its advanced stages. Melanoma is highly resistant to traditional chemotherapy and radiotherapy, although modern targeted therapies such as BRAF inhibitors are showing some promise. Photodynamic therapy (PDT, the combination of photosensitizing dyes and visible light) has been tested in the treatment of melanoma with some promising results, but melanoma is generally considered to be resistant to it. Optical interference by the highly-pigmented melanin, the antioxidant effect of melanin, the sequestration of photosensitizers inside melanosomes, defects in apoptotic pathways, and the efflux of photosensitizers by ATP-binding cassette transporters have all been implicated in melanoma resistance to PDT. Approaches to overcoming melanoma resistance to PDT include: the discovery of highly active photosensitizers absorbing in the 700-800-nm near infrared spectral region; interventions that can temporarily reduce the amount or pigmentation of the melanin; compounds that can reverse apoptotic defects or inhibit drug-efflux of photosensitizers; and immunotherapy approaches that can take advantage of the ability of PDT to activate the host immune system against the tumor being treated.en_US
dc.language.isoen_USen_US
dash.licenseLAA
dc.titleMelanoma Resistance to Photodynamic Therapy: New Insightsen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalBiological Chemistryen_US
dash.depositing.authorHamblin, Michael
dc.date.available2018-12-18T15:56:39Z
dash.workflow.comments1Science Serial ID 16560en_US
dc.identifier.doi10.1515/hsz-2012-0228
dash.source.volume394;2
dash.contributor.affiliatedHamblin, Michael
dc.identifier.orcid0000-0001-6431-4605


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