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dc.contributor.authorLin, Tsai-Yu
dc.contributor.authorChin, Christopher R.
dc.contributor.authorEveritt, Aaron R.
dc.contributor.authorClare, Simon
dc.contributor.authorPerreira, Jill M.
dc.contributor.authorSavidis, George
dc.contributor.authorJohn, Sinu P.
dc.contributor.authorSarlah, David
dc.contributor.authorCarreira, Erick M.
dc.contributor.authorKellam, Paul
dc.contributor.authorBrass, Abraham L.
dc.contributor.authorElledge, Stephen
dc.contributor.authorAker, Aaron
dc.contributor.authorjohn, sinu
dc.date.accessioned2018-12-19T12:18:55Z
dc.date.issued2013-11
dc.identifier.citationLin, Tsai-Yu, Christopher R. Chin, Aaron R. Everitt, Simon Clare, Jill M. Perreira, George Savidis, Aaron M. Aker, et al. 2013. “Amphotericin B Increases Influenza A Virus Infection by Preventing IFITM3-Mediated Restriction.” Cell Reports 5 (4): 895–908. https://doi.org/10.1016/j.celrep.2013.10.033.en_US
dc.identifier.issn2211-1247en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:37937843*
dc.description.abstractThe IFITMs inhibit influenza A virus (IAV) replication in vitro and in vivo. Here, we establish that the antimycotic heptaen, amphotericin B (AmphoB), prevents IFITM3-mediated restriction of IAV, thereby increasing viral replication. Consistent with its neutralization of IFITM3, a clinical preparation of AmphoB, AmBisome, reduces the majority of interferon's protective effect against IAV in vitro. Mechanistic studies reveal that IFITM1 decreases host-membrane fluidity, suggesting both a possible mechanism for IFITM-mediated restriction and its negation by AmphoB. Notably, we reveal that mice treated with AmBisome succumbed to a normally mild IAV infection, similar to animals deficient in Ifitm3. Therefore, patients receiving antifungal therapy with clinical preparations of AmphoB may be functionally immunocompromised and thus more vulnerable to influenza, as well as other IFITM3-restricted viral infections.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dash.licenseLAA
dc.titleAmphotericin B Increases Influenza A Virus Infection by Preventing IFITM3-Mediated Restrictionen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalCell Reportsen_US
dash.depositing.authorElledge, Stephen
dc.date.available2018-12-19T12:18:55Z
dash.workflow.comments1Science Serial ID 24794en_US
dc.identifier.doi10.1016/j.celrep.2013.10.033
dc.source.journalCell Reports
dash.source.volume5;4
dash.source.page895-908
dash.contributor.affiliatedAker, Aaron
dash.contributor.affiliatedElledge, Stephen


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