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dc.contributor.authorRobson, Philip M.
dc.contributor.authorMadhuranthakam, Ananth J.
dc.contributor.authorSmith, Martin P.
dc.contributor.authorSun, Maryellen R.M.
dc.contributor.authorDai, Weiying
dc.contributor.authorRofsky, Neil M.
dc.contributor.authorPedrosa, Ivan
dc.contributor.authorAlsop, David
dc.date.accessioned2019-01-10T15:05:00Z
dc.date.issued2016-02
dc.identifier.citationRobson, Philip M., Ananth J. Madhuranthakam, Martin P. Smith, Maryellen R.M. Sun, Weiying Dai, Neil M. Rofsky, Ivan Pedrosa, and David C. Alsop. 2016. “Volumetric Arterial Spin-Labeled Perfusion Imaging of the Kidneys with a Three-Dimensional Fast Spin Echo Acquisition.” Academic Radiology 23 (2): 144–54. https://doi.org/10.1016/j.acra.2015.09.013.en_US
dc.identifier.issn1076-6332en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:37980663*
dc.description.abstractRationale and Objectives: Renal perfusion measurements using noninvasive arterial spin-labeled (ASL) magnetic resonance imaging techniques are gaining interest. Currently, focus has been on perfusion in the context of renal transplant. Our objectives were to explore the use of ASL in patients with renal cancer, and to evaluate three-dimensional (3D) fast spin echo (FSE) acquisition, a robust volumetric imaging method for abdominal applications. We evaluate 3D ASL perfusion magnetic resonance imaging in the kidneys compared to two-dimensional (2D) ASL in patients and healthy subjects.Materials and Methods: Isotropic resolution (2.6 x 2.6 x 2.8 mm(3)) 3D ASL using segmented FSE was compared to 2D single-shot FSE. ASL used pseudo-continuous labeling, suppression of background signal, and synchronized breathing. Quantitative perfusion values and signal-to-noise ratio (SNR) were compared between 3D and 2D ASL in four healthy volunteers and semiquantitative assessments were made by four radiologists in four patients with known renal masses (primary renal cell carcinoma).Results: Renal cortex perfusion in healthy subjects was 284 +/- 21 mL/100 g/min, with test-retest repeatability of 8.8%. No significant differences were found between the quantitative perfusion value and SNR in volunteers between 3D ASL and 2D ASL, or in 3D ASL with synchronized or free breathing. In patients, semiquantitative assessment by radiologists showed no significant difference in image quality between 2D ASL and 3D ASL. In one case, 2D ASL missed a high perfusion focus in a mass that was seen by 3D ASL.Conclusions: 3D ASL renal perfusion imaging provides isotropic-resolution images, with comparable quantitative perfusion values and image SNR in similar imaging time to single-slice 2D ASL.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dash.licenseOAP
dc.subjectRadiology Nuclear Medicine and imagingen_US
dc.titleVolumetric Arterial Spin-labeled Perfusion Imaging of the Kidneys with a Three-dimensional Fast Spin Echo Acquisitionen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalAcademic Radiologyen_US
dash.depositing.authorAlsop, David
dc.date.available2019-01-10T15:05:00Z
dash.workflow.comments1scienceen_US
dc.identifier.doi10.1016/j.acra.2015.09.013
dc.source.journalAcademic Radiology
dash.source.volume23;2
dash.source.page144-154
dash.contributor.affiliatedAlsop, David


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