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dc.contributor.authorHayes, Jasmeet P.
dc.contributor.authorLogue, Mark W.
dc.contributor.authorSadeh, Naomi
dc.contributor.authorSpielberg, Jeffrey M.
dc.contributor.authorVerfaellie, Mieke
dc.contributor.authorHayes, Scott M.
dc.contributor.authorReagan, Andrew
dc.contributor.authorSalat, David H.
dc.contributor.authorWolf, Erika J.
dc.contributor.authorMcGlinchey, Regina E.
dc.contributor.authorStone, Annjanette
dc.contributor.authorSchichman, Steven A.
dc.contributor.authorMiller, Mark W.
dc.contributor.authorMilberg, William
dc.date.accessioned2019-01-14T15:08:29Z
dc.date.issued2017-01-11
dc.identifier.citationHayes, Jasmeet P., Mark W. Logue, Naomi Sadeh, Jeffrey M. Spielberg, Mieke Verfaellie, Scott M. Hayes, Andrew Reagan, et al. 2017. “Mild Traumatic Brain Injury Is Associated with Reduced Cortical Thickness in Those at Risk for Alzheimer’s Disease.” Brain, January, aww344. https://doi.org/10.1093/brain/aww344.en_US
dc.identifier.issn0006-8950en_US
dc.identifier.issn1460-2156en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:37989562*
dc.description.abstractModerate-to-severe traumatic brain injury is one of the strongest environmental risk factors for the development of neurodegenerative diseases such as late-onset Alzheimer's disease, although it is unclear whether mild traumatic brain injury, or concussion, also confers risk. This study examined mild traumatic brain injury and genetic risk as predictors of reduced cortical thickness in brain regions previously associated with early Alzheimer's disease, and their relationship with episodic memory. Participants were 160 Iraq and Afghanistan War veterans between the ages of 19 and 58, many of whom carried mild traumatic brain injury and post-traumatic stress disorder diagnoses. Whole-genome polygenic risk scores for the development of Alzheimer's disease were calculated using summary statistics from the largest Alzheimer's disease genome-wide association study to date. Results showed that mild traumatic brain injury moderated the relationship between genetic risk for Alzheimer's disease and cortical thickness, such that individuals with mild traumatic brain injury and high genetic risk showed reduced cortical thickness in Alzheimer's disease-vulnerable regions. Among males with mild traumatic brain injury, high genetic risk for Alzheimer's disease was associated with cortical thinning as a function of time since injury. A moderated mediation analysis showed that mild traumatic brain injury and high genetic risk indirectly influenced episodic memory performance through cortical thickness, suggesting that cortical thinning in Alzheimer's disease-vulnerable brain regions is a mechanism for reduced memory performance. Finally, analyses that examined the apolipoprotein E4 allele, post-traumatic stress disorder, and genetic risk for schizophrenia and depression confirmed the specificity of the Alzheimer's disease polygenic risk finding. These results provide evidence that mild traumatic brain injury is associated with greater neurodegeneration and reduced memory performance in individuals at genetic risk for Alzheimer's disease, with the caveat that the order of causal effects cannot be inferred from cross-sectional studies. These results underscore the importance of documenting head injuries even within the mild range as they may interact with genetic risk to produce negative long-term health consequences such as neurodegenerative disease.en_US
dc.language.isoen_USen_US
dc.publisherOxford University Press (OUP)en_US
dc.relation.isversionofhttps://academic.oup.com/brain/article-pdf/140/3/813/10793149/aww344.pdfen_US
dash.licenseMETA_ONLY
dc.titleMild Traumatic Brain Injury Is Associated With Reduced Cortical Thickness in Those at Risk for Alzheimer’s Diseaseen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBrainen_US
dash.depositing.authorMilberg, Williamen_US
dc.date.available2019-01-14T15:08:29Z
dash.workflow.comments1scienceen_US
dc.identifier.doi10.1093/brain/aww344
dc.source.journalBrain
dash.source.pageaww344
dash.contributor.affiliatedMilberg, William


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