Show simple item record

dc.contributor.authorQuan, Stuart
dc.date.accessioned2019-03-04T16:12:06Z
dc.date.issued2012
dc.identifier.citationQuan S. "Obstructive Sleep Apnea and Cardiovascular Disease: Back and Forward in Time over the Last 25 Years." Southwest Journal of Pulmonary and Critical Care 5 (2012): 206-17.en_US
dc.identifier.issn2160-6773en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:38561579*
dc.descriptionCitation: Quan SF. Obstructive sleep apnea and cardiovascular disease: back and forward in time over the last 25 years. Southwest J Pulm Crit Care 2012;5:206-17. URL: http://www.swjpcc.com/sleep/2012/10/19/obstructive-sleep-apnea-and-cardiovascular-disease-back-and.htmlen_US
dc.description.abstractOver the past 25 years, there have been significant advances made in understanding the pathophysiology and cardiovascular consequences of obstructive sleep apnea (OSA). Substantial evidence now implicates OSA as an independent risk factor for the development of hypertension, coronary artery disease, congestive heart failure and stroke, as well as increased risk of death. Pathophysiologic mechanisms include release of inflammatory mediators, oxidative stress, metabolic dysfunction, hypercoagulability and endothelial dysfunction. Although non-randomized intervention studies suggest that treatment of OSA with continuous positive airway pressure may mitigate its impact of the development of cardiovascular disease, randomized clinical trials are lacking.en_US
dc.language.isoen_USen_US
dc.relationSouthwest Journal of Pulmonary and Critical Careen_US
dash.licenseLAA
dc.subjectObstructive Sleep Apneaen_US
dc.titleObstructive Sleep Apnea and Cardiovascular Disease: Back and Forward in Time Over the Last 25 Yearsen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalSouthwest Journal of Pulmonary and Critical Careen_US
dc.date.available2019-03-04T16:12:06Z
dash.affiliation.otherHarvard Medical Schoolen_US
dash.contributor.affiliatedQuan, Stuart


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record