Characteristics and outcomes of nonmelanoma skin cancer (NMSC) in children and young adults
Author
Khosravi, Hasan
Metadata
Show full item recordCitation
Khosravi, Hasan. 2017. Characteristics and outcomes of nonmelanoma skin cancer (NMSC) in children and young adults. Doctoral dissertation, Harvard Medical School.Abstract
Background: Pediatric and young adult nonmelanoma skin cancer (NMSC) is rare and traditionally associated with predisposing heritable or congenital conditions. Clinical characteristics, outcomes, and iatrogenic risk factors have not been well described.Purpose: We sought to characterize clinical features, potential risk factors, and gaps in care associated with NMSC in children and young adults.
Methods: This was a retrospective chart review of children and young adults with squamous and basal cell carcinoma.
Results: We identified 28 patients with a total of 182 NMSC tumors. Of patients, 50% had predisposing conditions, and 46% had exposure to iatrogenic risk factors of prolonged immunosuppression, radiation therapy, chemotherapy, voriconazole use, or a combination of these. Of patients with iatrogenic risk factors, 62% developed subsequent cancerous or precancerous skin lesions. No patient was found to have chemotherapy or voriconazole exposure as a sole risk factor. Mean time to diagnosis of NMSC was 948 days with initial misdiagnosis in 36% of patients. The majority of patients underwent surgical excision.
Limitations: This was a retrospective single institution study with a small number of cases.
Conclusions: Physicians should be aware of risk factors associated with NMSC in children and young adults to provide appropriate counseling and early diagnosis and treatment.
Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:40621375
Collections
Contact administrator regarding this item (to report mistakes or request changes)