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dc.contributor.authorYang, Xiao
dc.contributor.authorZhou, Tao
dc.contributor.authorZwang, Theodore
dc.contributor.authorHong, Guosong
dc.contributor.authorZhao, Yunlong
dc.contributor.authorViveros, Robert D.
dc.contributor.authorFu, Tian-Ming
dc.contributor.authorGao, Teng
dc.contributor.authorLieber, Charles
dc.date.accessioned2019-08-02T13:48:44Z
dc.date.issued2019-02-25
dc.identifier.citationYang, Xiao, Tao Zhou, Theodore Zwant, Guosong Hong, Yunlong Zhao, et al. 2019. Bioinspired neuron-like electronics. Nature Materials 18: 510-517. doi: 10.1038/s41563-019-0292-9en_US
dc.identifier.issn1476-1122en_US
dc.identifier.issn1476-4660en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41060390*
dc.description.abstractAs an important application of functional biomaterials, neural probes have contributed substantially to studying the brain. Bioinspired and biomimetic strategies have begun to be applied to the development of neural probes, although these and previous generations of probes have had structural and mechanical dissimilarities from their neuron targets that lead to neuronal loss, neuroinflammatory responses and measurement instabilities. Here, we present a bioinspired design for neural probes—neuron-like electronics (NeuE)—where the key building blocks mimic the subcellular structural features and mechanical properties of neurons. Full three-dimensional mapping of implanted NeuE–brain interfaces highlights the structural indistinguishability and intimate interpenetration of NeuE and neurons. Time-dependent histology and electrophysiology studies further reveal a structurally and functionally stable interface with the neuronal and glial networks shortly following implantation, thus opening opportunities for next-generation brain–machine interfaces. Finally, the NeuE subcellular structural features are shown to facilitate migration of endogenous neural progenitor cells, thus holding promise as an electrically active platform for transplantation-free regenerative medicine.en_US
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.relationNature Materialsen_US
dash.licenseMETA_ONLY
dc.subjectMechanical Engineeringen_US
dc.subjectGeneral Materials Scienceen_US
dc.subjectMechanics of Materialsen_US
dc.subjectGeneral Chemistryen_US
dc.subjectCondensed Matter Physicsen_US
dc.titleBioinspired neuron-like electronicsen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalNature Materialsen_US
dash.depositing.authorLieber, Charles
dash.waiver2019-01-15
dc.date.available2019-08-02T13:48:44Z
dash.affiliation.otherFaculty of Arts & Sciencesen_US
dc.identifier.doi10.1038/s41563-019-0292-9
dc.source.journalNat. Mater.
dash.source.volume18;5
dash.source.page510-517
dash.contributor.affiliatedZwang, Theodore
dash.contributor.affiliatedZhao, Yunlong
dash.contributor.affiliatedYang, Xiao
dash.contributor.affiliatedGao, Teng
dash.contributor.affiliatedZhou, Tao
dash.contributor.affiliatedFu, Tian-Ming
dash.contributor.affiliatedLieber, Charles


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