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dc.contributor.advisorHarvey, Christopher D.
dc.contributor.authorPatella, Paola
dc.date.accessioned2019-08-08T09:20:37Z
dash.embargo.terms2021-03-01
dc.date.created2019-03
dc.date.issued2019-01-20
dc.date.submitted2019
dc.identifier.citationPatella, Paola. 2019. Mechanosensory Representations in the Drosophila Brain. Doctoral dissertation, Harvard University, Graduate School of Arts & Sciences.
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41121300*
dc.description.abstractJohnston’s organ is the largest mechanosensory organ in Drosophila. It contributes to hearing, touch, vestibular sensing, proprioception, and wind sensing. In the first part of this study, we used in vivo 2-photon calcium imaging and unsupervised image segmentation to map the tuning properties of Johnston’s organ neurons (JONs) at the site where their axons enter the brain. We then applied the same methodology to study two key brain regions that process signals from JONs: the antennal mechanosensory and motor center (AMMC) and the wedge, which is downstream of the AMMC. We found that, whereas JONs form a rough tonotopic map, the AMMC and wedge contain progressively finer and more orderly tonotopic maps. Whereas the AMMC tonotopic map is unilateral, the wedge tonotopic map is bilateral. We also observed the emergence of bilaterality in the regions of the AMMC and wedge that respond preferentially to steady wind. Together, these maps reveal the broad organization of the primary and secondary mechanosensory regions of the brain. They provide a framework for future efforts to identify the specific cell types and mechanisms that underlie the hierarchical re-mapping of mechanosensory information in this system. In the second part of this study, we examined how information about wind direction, which is transduced through JONs, influences the brain’s heading direction “compass” in the central complex. We identified neurons that provide input to the central complex from the brain’s mechanosensory regions. We also showed that these neurons have properties which should allow them to encode wind direction in a manner which is robust to wind intensity.
dc.description.sponsorshipMedical Sciences
dc.format.mimetypeapplication/pdf
dc.language.isoen
dash.licenseLAA
dc.subjectWED
dc.subjectauditory
dc.subjectchordotonal
dc.subjecthearing
dc.subjectphase
dc.subjectselectivity
dc.subjectsound
dc.subjectvibration
dc.subjectwind
dc.subjectbilaterality
dc.subjectheading
dc.titleMechanosensory Representations in the Drosophila Brain
dc.typeThesis or Dissertation
dash.depositing.authorPatella, Paola
dash.embargo.until2021-03-01
dc.date.available2019-08-08T09:20:37Z
thesis.degree.date2019
thesis.degree.grantorGraduate School of Arts & Sciences
thesis.degree.grantorGraduate School of Arts & Sciences
thesis.degree.levelDoctoral
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy
thesis.degree.nameDoctor of Philosophy
dc.contributor.committeeMemberAndermann, Mark L.
dc.contributor.committeeMemberAssad, John A.
dc.contributor.committeeMemberTaube, Jeffrey S.
dc.type.materialtext
thesis.degree.departmentMedical Sciences
thesis.degree.departmentMedical Sciences
dash.identifier.vireo
dc.identifier.orcid0000-0003-2409-5182
dash.author.emailpatella.paola@gmail.com


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