Show simple item record

dc.contributor.authorMaeda, Kazuhisa
dc.contributor.authorCao, Haiming
dc.contributor.authorKono, Keita
dc.contributor.authorGorgun, Cem Z.
dc.contributor.authorFuruhashi, Masato
dc.contributor.authorUysal, Kadir T.
dc.contributor.authorCao, Qiong
dc.contributor.authorAtsumi, Genichi
dc.contributor.authorMalone, Harry
dc.contributor.authorKrishnan, Bala
dc.contributor.authorMinokoshi, Yasuhiko
dc.contributor.authorKahn, Barbara B.
dc.contributor.authorParker, Rex A.
dc.contributor.authorHotamisligil, Gokhan
dc.date.accessioned2019-08-19T11:14:18Z
dc.date.issued2005-02
dc.identifier.citationMaeda, Kazuhisa, Haiming Cao, Keita Kono, Cem Z. Gorgun, Masato Furuhashi, Kadir T. Uysal, Qiong Cao, et al. 2005. “Adipocyte/Macrophage Fatty Acid Binding Proteins Control Integrated Metabolic Responses in Obesity and Diabetes.” Cell Metabolism 1 (2): 107–19. https://doi.org/10.1016/j.cmet.2004.12.008.en_US
dc.identifier.issn1550-4131en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41200929*
dc.description.abstractFatty acid binding proteins (FABPs) are cytosolic fatty acid chaperones whose biological role and mechanisms of action are not well understood. Here, we developed mice with targeted mutations in two related adipocyte FABPs, aP2 and mal1, to resolve their role in systemic lipid, glucose, and energy metabolism. Mice lacking aP2 and mail exhibited a striking phenotype with strong protection from diet-induced obesity, insulin resistance, type 2 diabetes, and fatty liver disease. These mice have altered cellular and systemic lipid transport and composition, leading to enhanced insulin receptor signaling, enhanced muscle AMP-activated kinase (AMP-K) activity, and dramatically reduced liver stearoyl-CoA desaturase-1 (SCD-1) activity underlying their phenotype. Taken together with the previously reported strong protection against atherosclerosis, these results demonstrate that adipocyte/macrophage FABPs have a robust impact on multiple components of metabolic syndrome, integrating metabolic and inflammatory responses in mice and constituting a powerful target for the treatment of these diseases.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dash.licenseMETA_ONLY
dc.titleAdipocyte/macrophage Fatty Acid Binding Proteins Control Integrated Metabolic Responses in Obesity and Diabetesen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalCell Metabolismen_US
dash.depositing.authorHotamisligil, Gokhan
dc.date.available2019-08-19T11:14:18Z
dash.workflow.comments1scienceen_US
dc.identifier.doi10.1016/j.cmet.2004.12.008
dc.source.journalCell Metabolism
dash.source.volume1;2
dash.source.page107-119
dash.contributor.affiliatedHotamisligil, Gokhan


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record