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dc.contributor.authorAscherio, A.
dc.contributor.authorRimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
dc.contributor.authorHernan, M. A.
dc.contributor.authorGiovannucci, E. L.
dc.contributor.authorKawachi, I.
dc.contributor.authorStampfer, Meir
dc.contributor.authorWillett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600
dc.date.accessioned2019-08-25T13:31:12Z
dc.date.issued1998
dc.identifier.citationAscherio, A., E. B. Rimm, M. A. Hernán, E. L. Giovannucci, I. Kawachi, M. J. Stampfer, and W. C. Willett. 1998. “Intake of Potassium, Magnesium, Calcium, and Fiber and Risk of Stroke Among US Men.” Circulation 98 (12): 1198–1204. https://doi.org/10.1161/01.cir.98.12.1198.
dc.identifier.issn0009-7322
dc.identifier.issn0069-4193
dc.identifier.issn1524-4539
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41245535*
dc.description.abstractBackground-Animal experiments and epidemiological studies have suggested that high potassium intake may reduce the risk of stroke, but the evidence is inconclusive, and the role of other nutrients in potassium-rich foods remains unknown.Methods and Results-We examined the association of potassium and related nutrients with risk of stroke among 43 738 US men, 40 to 75 years old, without diagnosed cardiovascular diseases or diabetes, who completed a semiquantitative food frequency questionnaire in 1986. During 8 years of follow-up, 328 strokes (210 ischemic, 70 hemorrhagic, 48 unspecified) were documented. The multivariate relative risk of stroke of any type for men in the top fifth of potassium intake (median intake, 4.3 g/d) versus those in the bottom (median, 2.4 g/d) was 0.62 (95% CI, 0.43, 0.88; P for trend=0.007). Results for ischemic stroke alone were similar. Intakes of cereal fiber and magnesium, but not of calcium, were also inversely associated with risk of total stroke. These inverse associations were all stranger in hypertensive than normotensive men and were not materially altered by adjustment for blood pressure levels. Use of potassium supplements was also inversely related to risk of stroke, particularly among men taking diuretics (relative risk, 0.36; 95% CI, 0.18, 0.72).Conclusions-Although these data do not prove a causal relationship, they are consistent with the hypothesis that diets rich in potassium, magnesium, and cereal fiber reduce the risk of stroke, particularly among hypertensive men. Potassium supplements may also be beneficial, but because of potential risks, use should be carefully monitored and restricted to men taking potassium-losing diuretics.
dc.language.isoen_US
dc.publisherAmerican Heart Association
dash.licenseMETA_ONLY
dc.titleIntake of Potassium, Magnesium, Calcium, and Fiber and Risk of Stroke Among US Men
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalCirculation
dash.depositing.authorRimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
dc.date.available2019-08-25T13:31:12Z
dash.workflow.comments1Science Serial ID 20816
dc.identifier.doi10.1161/01.CIR.98.12.1198
dash.source.volume98;12
dash.source.page1198-1204
dash.contributor.affiliatedStampfer, Meir


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