A Meta-Analysis Shows That Docosahexaenoic Acid from Algal Oil Reduces Serum Triglycerides and Increases HDL-Cholesterol and LDL-Cholesterol in Persons without Coronary Heart Disease
View/ Open
111942 99.pdf (730.2Kb)
Access Status
Full text of the requested work is not available in DASH at this time ("restricted access"). For more information on restricted deposits, see our FAQ.Author
Bernstein, A. M.
Ding, E. L.
Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600
Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
Published Version
https://doi.org/10.3945/jn.111.148973Metadata
Show full item recordCitation
Bernstein, Adam M., Eric L. Ding, Walter C. Willett, and Eric B. Rimm. 2011. “A Meta-Analysis Shows That Docosahexaenoic Acid from Algal Oil Reduces Serum Triglycerides and Increases HDL-Cholesterol and LDL-Cholesterol in Persons without Coronary Heart Disease.” The Journal of Nutrition 142 (1): 99–104. https://doi.org/10.3945/jn.111.148973.Abstract
Certain algae contain the (n-3) fatty acid DHA, yet the relation between algal oil supplementation and cardiovascular disease risk factors has not been systematically examined. Our objective was to examine the relation between algal oil supplementation and cardiovascular disease risk factors. We conducted a systematic review of randomized controlled trials published between 1996 and 2011 examining the relation between algal oil supplementation and cardiovascular disease risk factors and performed a meta-analysis of the association between algal oil DHA supplementation and changes in the concentrations of TG, LDL-cholesterol (LDL-C), and HDL-cholesterol (HDL-C). We identified 11 randomized controlled trials with 485 healthy participants that evaluated the relation between algal oil DHA supplementation and TG, LDL-C, and HDL-C. The median dose of algal DHA was 1.68 g/d. The pooled estimate for the change in TG concentration was -0.20 mmol/L (95% Cl: -0.27 to -0.14), 0.23 mmol/L (95% Cl: 0.16-0.30) for LDL-C, and 0.07 mmol/L 195% Cl: 0.05-0.101 for HDL-C. DHA supplementation from algal oil, a marine source of (n-3) fatty acids not extracted from fish, may reduce serum TG and increase HDL-C and LDL-C in persons without coronary heart disease. J. Nutr. 142: 99-104, 2012.Citable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:41246927
Collections
- SPH Scholarly Articles [6329]
Contact administrator regarding this item (to report mistakes or request changes)