Genome-Wide Meta-Analysis Identifies Regions on 7p21 (AHR) and 15q24 (CYP1A2) As Determinants of Habitual Caffeine Consumption

 
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Cornelis, Marilyn C.
Monda, Keri L.
Yu, Kai
Paynter, Nina
Azzato, Elizabeth M.
Bennett, Siiri N.
Berndt, Sonja I.
Boerwinkle, Eric
Chanock, Stephen
Chatterjee, Nilanjan
Couper, David
Curhan, Gary
Heiss, Gerardo
Hu, Frank B.
Hunter, David J.
Jacobs, Kevin
Jensen, Majken K.
Kraft, Peter
Landi, Maria Teresa
Nettleton, Jennifer A.
Purdue, Mark P.
Rajaraman, Preetha
Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
Rose, Lynda M.
Rothman, Nathaniel
Silverman, Debra
Stolzenberg-Solomon, Rachael
Subar, Amy
Yeager, Meredith
Chasman, Daniel I.
van Dam, Rob M.
Caporaso, Neil E.
Gibson, Greg
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https://doi.org/10.1371/journal.pgen.1002033
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Cornelis, Marilyn C., Keri L. Monda, Kai Yu, Nina Paynter, Elizabeth M. Azzato, Siiri N. Bennett, Sonja I. Berndt, et al. 2011. “Genome-Wide Meta-Analysis Identifies Regions on 7p21 (AHR) and 15q24 (CYP1A2) As Determinants of Habitual Caffeine Consumption.” Edited by Greg Gibson. PLoS Genetics 7 (4): e1002033. https://doi.org/10.1371/journal.pgen.1002033.
Abstract
We report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States. In a meta-analysis adjusted for age, sex, smoking, and eigenvectors of population variation, two loci achieved genome-wide significance: 7p21 (P = 2.4x10(-19)), near AHR, and 15q24 (P = 5.2x10(-14)), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2.
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http://nrs.harvard.edu/urn-3:HUL.InstRepos:41246960

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