Show simple item record

dc.contributor.authorGiovannucci, Edward
dc.contributor.authorLiu, Yan
dc.contributor.authorRimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
dc.contributor.authorHollis, Bruce W.
dc.contributor.authorFuchs, Charles S.
dc.contributor.authorStampfer, Meir
dc.contributor.authorWillett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600
dc.date.accessioned2019-08-26T15:17:24Z
dc.date.issued2006
dc.identifier.citationGiovannucci, Edward, Yan Liu, Eric B. Rimm, Bruce W. Hollis, Charles S. Fuchs, Meir J. Stampfer, and Walter C. Willett. 2006. “Prospective Study of Predictors of Vitamin D Status and Cancer Incidence and Mortality in Men.” JNCI: Journal of the National Cancer Institute 98 (7): 451–59. https://doi.org/10.1093/jnci/djj101.
dc.identifier.issn0027-8874
dc.identifier.issn0198-0157
dc.identifier.issn1460-2105
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41247253*
dc.description.abstractBackground: Vitamin D has potent anticancer properties, especially against digestive-system cancers. Many human studies have used geographic residence as a marker of solar ultraviolet B and hence vitamin D exposure. Here, we considered multiple determinants of vitamin D exposure (dietary and supplementary vitamin D, skin pigmentation, adiposity, geographic residence, and leisure-time physical activity-to estimate sunlight exposure) in relation to cancer risk in the Health Professionals Follow-Up Study. Methods: Among 1095 men of this cohort, we quantified the relation of these six determinants to plasma 25-hydroxy-vitamin D vertical bar 25(OH)D vertical bar level by use of a multiple linear regression model. We used results from the model to compute a predicted 25(OH)D level for each of 47800 men in the cohort based on these characteristics. We then prospectively examined this variable in relation to cancer risk with multivariable Cox proportional hazards models. Results: From 1986 through January 31, 2000, we documented 4286 incident cancers (excluding organ-confined prostate cancer and nonmelanoma skin cancer) and 2025 deaths from cancer. From multivariable models, an increment of 25 nmol/L in predicted 25(OH)D level was associated with a 17% reduction in total cancer incidence (multivariable relative risk [RR] = 0.83, 95% confidence interval vertical bar CI vertical bar 0.74 to 0.92), a 29% reduction in total cancer mortality (RR 0.71, 95% CI = 0.60 to 0.83), and a 45% reduction in digestive-system cancer mortality (RR = 0.55, 95% CI = 0.41 to 0.74). The absolute annual rate of total cancer was 758 per 100000 men in the bottom decile of predicted 25(OH)D and 674 per 100000 men for the top decile; these respective rates were 326 per 100000 and 277 per 100000 for total cancer mortality and 128 per 100000 and 78 per 100000 for digestive-system cancer mortality. Results were similar when we controlled further for body mass index or physical activity level. Conclusions: Low levels of vitamin D may be associated with increased cancer incidence and mortality in men, particularly for digestive-system cancers. The vitamin D supplementation necessary to achieve a 25(OH)D increment of 25 nmol/L may be at least 1500 IU/day.
dc.language.isoen_US
dc.publisherOxford University Press
dash.licenseMETA_ONLY
dc.titleProspective Study of Predictors of Vitamin D Status and Cancer Incidence and Mortality in Men
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalJournal of the National Cancer Institute
dash.depositing.authorRimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
dc.date.available2019-08-26T15:17:24Z
dash.workflow.comments1Science Serial ID 57256
dc.identifier.doi10.1093/jnci/djj101
dash.source.volume98;7
dash.source.page451-459
dash.contributor.affiliatedStampfer, Meir


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record