Novel Loci Associated with Usual Sleep Duration: The CHARGE Consortium Genome-Wide Association Study
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Author
Gottlieb, Daniel
Hek, Karin
Chen, Ting-hsu
Watson, Nathaniel
Eiriksdottir, Gudny
Byrne, Enda
Cornelis, Marilyn
Warby, Simon
Bandinelli, Stefania
Cherkas, Lynn
Evans, Daniel
Grabe, Hans
Lahti, Jari
Li, Man
Lehtimäki, Terho
Lumley, Thomas
Marciante, Kristin
Pérusse, Louis
Psaty, Bruce
Robbins, John
Tranah, Gregory
Vink, Jacqueline
Wilk, Jemma
Stafford, Jeanette
Bellis, Claire
Biffar, Reiner
Bouchard, Claude
Cade, Brian
Curhan, Gary
Eriksson, Johan
Ewert, Ralf
Ferrucci, Luigi
Fülöp, Tibor
Gehrman, Philip
Goodloe, Robert
Harris, Tamara
Heath, Andrew
Hernandez, Dena
Hofman, Albert
Hottenga, Jouke-Jan
Hunter, David
Jensen, Majken
Johnson, Andrew
Kähönen, Mika
Kao, Linda
Kraft, Peter
Larkin, Emma
Lauderdale, Diane
Luik, Annemarie
Medici, Marco
Montgomery, Grant
Palotie, Aarno
Patel, Sanjay
Pistis, Giorgio
Porcu, Eleonora
Quaye, Lydia
Raitakari, Olli
Redline, Susan
Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
Rotter, Jerome
Smith, Albert
Spector, Tim
Teumer, Alexander
Uitterlinden, André G.
Vohl, Marie-Claude
Widen, Elisabeth
Willemsen, Gonneke
Young, Terry
Zhang, Xiaoling
Liu, Yongmei
Blangero, John
Boomsma, Dorret
Gudnason, Vilmundur
Hu, Frank
Mangino, Massimo
Martin, Nicholas
O’Connor, George T.
Stone, Katie
Tanaka, Toshiko
Viikari, Jorma
Gharib, Sina
Punjabi, Naresh
Räikkönen, Katri
Völzke, Henry
Mignot, Emmanuel
Tiemeier, Henning
Published Version
https://doi.org/10.1038/mp.2014.133Metadata
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Gottlieb, D J, K Hek, T-h Chen, N F Watson, G Eiriksdottir, E M Byrne, M Cornelis, et al. 2014. “Novel Loci Associated with Usual Sleep Duration: The CHARGE Consortium Genome-Wide Association Study.” Molecular Psychiatry 20 (10): 1232–39. https://doi.org/10.1038/mp.2014.133.Abstract
Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic disease and mortality, although little is known about the genetic variants influencing this trait. A genome-wide association study (GWAS) of usual sleep duration was conducted using 18 population-based cohorts totaling 47 180 individuals of European ancestry. Genome-wide significant association was identified at two loci. The strongest is located on chromosome 2, in an intergenic region 35- to 80-kb upstream from the thyroid-specific transcription factor PAX8 (lowest P = 1.1 x 10(-9)). This finding was replicated in an African-American sample of 4771 individuals (lowest P = 9.3 x 10(-4)). The strongest combined association was at rs1823125 (P = 1.5 x 10(-10), minor allele frequency 0.26 in the discovery sample, 0.12 in the replication sample), with each copy of the minor allele associated with a sleep duration 3.1 min longer per night. The alleles associated with longer sleep duration were associated in previous GWAS with a more favorable metabolic profile and a lower risk of attention deficit hyperactivity disorder. Understanding the mechanisms underlying these associations may help elucidate biological mechanisms influencing sleep duration and its association with psychiatric, metabolic and cardiovascular disease.Terms of Use
This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAPCitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:41247264
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