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dc.contributor.authorMozaffarian, Dariush
dc.contributor.authorRimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
dc.contributor.authorHerrington, David M.
dc.date.accessioned2019-08-26T16:11:17Z
dc.date.issued2004
dc.identifier.citationMozaffarian, Dariush, Eric B Rimm, and David M Herrington. 2004. “Dietary Fats, Carbohydrate, and Progression of Coronary Atherosclerosis in Postmenopausal Women.” The American Journal of Clinical Nutrition 80 (5): 1175–84. https://doi.org/10.1093/ajcn/80.5.1175.
dc.identifier.issn0002-9165
dc.identifier.issn1938-3207
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41249131*
dc.description.abstractBackground: The influence of diet on atherosclerotic progression is not well established, particularly in postmenopausal women, in whom risk factors for progression may differ from those for men. Objective: The objective was to investigate associations between dietary macronutrients and progression of coronary atherosclerosis among postmenopausal women. Design: Quantitative coronary angiography was performed at baseline and after a mean follow-up of 3.1 y in 2243 coronary segments in 235 postmenopausal women with established coronary heart disease. Usual dietary intake was assessed at baseline. Results: The mean (+/-SD) total fat intake was 25+/-6% of energy. In multivariate analyses. a higher saturated fat intake was associated with a smaller decline in mean minimal coronary diameter (P = 0.001) and less progression of coronary stenosis (P = 0.002) during follow-up. Compared with a 0.22-mm decline in the lowest quartile of intake. there was a 0.10-mm decline in the second quartile (P = 0.002), a 0.07-mm decline in the third quartile (P = 0.002), and no decline in the fourth quartile (P < 0.001); P for trend = 0.001. This inverse association was more pronounced among women with lower monounsaturated fat (P for interaction = 0.04) and higher carbohydrate (P for interaction 0.004) intakes and possibly lower total fat intake (P for interaction 0.09). Carbohydrate intake was positively associated with atherosclerotic progression (P = 0.001), particularly when the glycemic index was high. Polyunsaturated fat intake was positively associated with progression when replacing other fats (P = 0.04) but not when replacing carbohydrate or protein. Monounsaturated and total fat intakes were not associated with progression. Conclusions: In postmenopausal women with relatively low total fat intake, a greater saturated fat intake is associated with less progression of coronary atherosclerosis. whereas carbohydrate intake is associated with a greater progression.
dc.language.isoen_US
dc.publisherOxford University Press
dash.licenseMETA_ONLY
dc.titleDietary fats, carbohydrate, and progression of coronary atherosclerosis in postmenopausal women
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalAmerican Journal of Clinical Nutrition
dash.depositing.authorRimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
dc.date.available2019-08-26T16:11:17Z
dash.workflow.comments1Science Serial ID 1513
dc.identifier.doi10.1093/ajcn/80.5.1175
dash.source.volume80;5
dash.source.page1175-1184


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