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dc.contributor.authorSchulze, Matthias
dc.contributor.authorLiu, Simin
dc.contributor.authorRimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
dc.contributor.authorManson, Joann
dc.contributor.authorWillett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600
dc.contributor.authorHu, Frank
dc.date.accessioned2019-08-26T16:11:18Z
dc.date.issued2004
dc.identifier.citationSchulze, Matthias B, Liu, Simin, Rimm, Eric B, Manson, JoAnn E, Willett, Walter C, Hu, Frank B. 2004. 'Glycemic index, glycemic load, and dietary fiber intake and incidence of type 2 diabetes in younger and middle-aged women.' The American Journal of Clinical Nutrition 80, 2: 348-356. https://doi.org/10.1093/ajcn/80.2.348
dc.identifier.issn0002-9165
dc.identifier.issn1938-3207
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41249134*
dc.description.abstractBackground: Increasing evidence suggests an important role of carbohydrate quality in the development of type 2 diabetes. Objective: Our objective was to prospectively examine the association between glycemic index, glycemic load, and dietary fiber and the risk of type 2 diabetes in a large cohort of young women. Design: In 1991,91249 women completed a semiquantitative food-frequency questionnaire that assessed dietary intake. The women were followed for 8 y for the development of incident type 2 diabetes, and dietary information was updated in 1995. Results: We identified 741 incident cases of confirmed type 2 diabetes during 8 y (716 300 person-years) of follow-up. After adjustment for age, body mass index, family history of diabetes, and other potential confounders, glycemic index was significantly associated with an increased risk of diabetes (multivariate relative risks for quintiles 1-5, respectively: 1, 1.15, 1.07, 1.27, and 1.59; 95% CI: 1.21, 2.10; P for trend = 0.001). Conversely, cereal fiber intake was associated with a decreased risk of diabetes (multivariate relative risks for quintiles 1-5, respectively: 1, 0.85, 0.87, 0.82, and 0.64; 95% Cl: 0.48, 0.86; P for trend = 0.004). Glycemic load was not significantly associated with risk in the overall cohort (multivariate relative risks for quintiles 1-5, respectively: 1, 1.31, 1.20, 1.14, and 1.33; 95% Cl: 0.92, 1.91; P for trend = 0.21). Conclusions: A diet high in rapidly absorbed carbohydrates and low in cereal fiber is associated with an increased risk of type 2 diabetes.
dc.language.isoen_US
dc.publisherOxford University Press
dash.licenseMETA_ONLY
dc.titleGlycemic index, glycemic load, and dietary fiber intake and incidence of type 2 diabetes in younger and middle-age women
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalAmerican Journal of Clinical Nutrition
dash.depositing.authorRimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
dc.date.available2019-08-26T16:11:18Z
dash.workflow.comments1Science Serial ID 1518
dc.identifier.doi10.1093/ajcn/80.2.348
dash.source.volume80;2
dash.source.page348-56


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