dc.contributor.author | Hu, F. B. | |
dc.contributor.author | Stampfer, Meir | |
dc.contributor.author | Manson, J. E. | |
dc.contributor.author | Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600 | |
dc.contributor.author | Wolk, A. | |
dc.contributor.author | Colditz, G. A. | |
dc.contributor.author | Hennekens, C. H. | |
dc.contributor.author | Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600 | |
dc.date.accessioned | 2019-08-26T16:11:42Z | |
dc.date.issued | 1999 | |
dc.identifier.citation | Hu, Frank B, Meir J Stampfer, JoAnn E Manson, Eric B Rimm, Alicja Wolk, Graham A Colditz, Charles H Hennekens, and Walter C Willett. 1999. “Dietary Intake of α-Linolenic Acid and Risk of Fatal Ischemic Heart Disease among Women.” The American Journal of Clinical Nutrition 69 (5): 890–97. https://doi.org/10.1093/ajcn/69.5.890. | |
dc.identifier.issn | 0002-9165 | |
dc.identifier.issn | 1938-3207 | |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:41249199 | * |
dc.description.abstract | Background: Experimental studies in laboratory animals and humans suggest that alpha-linolenic acid (18:3n-3) may reduce the risk of arrhythmia. Objective: The objective was to examine the association between dietary intake of alpha-linolenic acid and risk of fatal ischemic heart disease (IHD). Design: This was a prospective cohort study. The intake of alpha-linolenic acid was derived from a 116-item food-frequency questionnaire completed in 1984 by 76283 women without previously diagnosed cancer or cardiovascular disease. Results: During 10 y of follow-up, we documented 232 cases of fatal IHD and 597 cases of nonfatal myocardial infarction. After adjustment for age, standard coronary risk factors, and dietary intake of linoleic acid and other nutrients, a higher intake of alpha-linolenic acid was associated with a lower relative risk (RR) of fatal IHD; the RRs from the lowest to highest quintiles were 1.0, 0.99, 0.90, 0.67, and 0.55 (95% CI: 0.32, 0.94; P for trend = 0.01). For nonfatal myocardial infarction there was only a modest, nonsignificant trend toward a reduced risk when extreme quintiles were compared (RR: 0.85; 95% CI: 0.61, 1.19; P for trend = 0.50). A higher intake of oil and vinegar salad dressing, an important source of alpha-linolenic acid, was associated with reduced risk of fatal IHD when women who consumed this food greater than or equal to 5-6 times/wk were compared with those who rarely consumed this food (RR: 0.46; 95% CI: 0.27, 0.76; P for trend = 0.001). Conclusions: This study supports the hypothesis that a higher intake of alpha-linolenic acid is protective against fatal IHD. Higher consumption of foods such as oil-based salad dressing that provide polyunsaturated fats, including alpha-linolenic acid, may reduce the risk of fatal IHD. | |
dc.language.iso | en_US | |
dc.publisher | Oxford University Press | |
dash.license | META_ONLY | |
dc.title | Dietary intake of alpha-linolenic acid and risk of fatal ischemic heart disease among women | |
dc.type | Journal Article | |
dc.description.version | Version of Record | |
dc.relation.journal | American Journal of Clinical Nutrition | |
dash.depositing.author | Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600 | |
dc.date.available | 2019-08-26T16:11:42Z | |
dash.workflow.comments | 1Science Serial ID 1461 | |
dc.identifier.doi | 10.1093/ajcn/69.5.890 | |
dash.source.volume | 69;5 | |
dash.source.page | 890-897 | |
dash.contributor.affiliated | Stampfer, Meir | |