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dc.contributor.authorMukamal, Kenneth J.
dc.contributor.authorPai, Jennifer K.
dc.contributor.authorJensen, Majken K.
dc.contributor.authorRimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
dc.date.accessioned2019-08-27T12:48:10Z
dc.date.issued2009
dc.identifier.citationMukamal, Kenneth J., Jennifer K. Pai, Majken K. Jensen, and Eric B. Rimm. 2009. “Paraoxonase 1 Polymorphisms and Risk of Myocardial Infarction in Women and Men.” Circulation Journal 73 (7): 1302–7. https://doi.org/10.1253/circj.cj-08-0912.
dc.identifier.issn1346-9843
dc.identifier.issn1347-4820
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41254595*
dc.description.abstractBackground: Previous studies of genetic variants of paraoxonase 1 (PONI) and coronary heart disease (CHD) have been conflicting and the modifying effects of lifestyle factors that affect PONI activity are uncertain.Methods and Results: In parallel nested case-control studies, the prospective associations between PONI polymorphisms Q192R and L55M and incident CHD were examined among participants in the Nurses' Health and Health Professionals Follow-up Studies. Women were followed for 8 years and men for 6 years, and 249 women and 266 men were documented with incident CHID. Neither polymorphism was associated with risk of CHD in either sex, and neither monounsaturated fat intake nor smoking interacted with genotype. Among women, there was a possible interaction of Q192R with alcohol intake (P interaction 0.06) and a suggestion of a similar interaction with the L55M genotype (P interaction 0.11). In analyses of both polymorphisms, alcohol intake >= 2.5 g/day was associated with lower risk among all women (odds ratio 0.45), except those with the Q192Q/L55M genotype (OR 1.33; P 3-way interaction 0.07). Conclusions: PONI polymorphisms are not associated with the risk of CHD nor do they interact with smoking or monounsaturated fat intake. A possible gene-alcohol interaction should be considered in future studies of PONI and CHID. (Circ J 2009; 73: 1302-1307)
dc.language.isoen_US
dash.licenseLAA
dc.titleParaoxonase 1 Polymorphisms and Risk of Myocardial Infarction in Women and Men
dc.typeJournal Article
dc.description.versionAccepted Manuscript
dc.relation.journalCirculation Journal - Official Journal of the Japanese Circulation Society
dash.depositing.authorRimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
dc.date.available2019-08-27T12:48:10Z
dash.workflow.comments1Science Serial ID 25149
dc.identifier.doi10.1253/circj.cj-08-0912
dash.source.volume73;7
dash.source.page1302


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