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dc.contributor.authorYang, Shuman
dc.contributor.authorJensen, Majken
dc.contributor.authorRimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
dc.contributor.authorWillett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600
dc.contributor.authorWu, Tianying
dc.date.accessioned2019-08-27T12:48:21Z
dc.date.issued2014
dc.identifier.citationYang, Shuman, Majken K. Jensen, Eric B. Rimm, Walter Willett, and Tianying Wu. 2014. “Erythrocyte Superoxide Dismutase, Glutathione Peroxidase, and Catalase Activities and Risk of Coronary Heart Disease in Generally Healthy Women: A Prospective Study.” American Journal of Epidemiology 180 (9): 901–8. https://doi.org/10.1093/aje/kwu195.
dc.identifier.issn0002-9262
dc.identifier.issn1476-6256
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41254613*
dc.description.abstractErythrocyte antioxidant enzymes are major circulating antioxidant enzymes in the oxidative stress defense system. Few prospective studies have assessed the association between these enzymes and the risk of coronary heart disease (CHD) in generally healthy adults. We conducted a prospective nested case-control study of CHD among 32,826 women at baseline with 15 years of follow-up from 1989 to 2004 in the Nurses' Health Study. We investigated the association of baseline erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activities with the risk of CHD. A total of 365 cases and 728 controls were included in the analysis. Overall, the relative risks of CHD associated with 1-standard deviation higher SOD, GPx, and CAT activities were 1.07 (95% confidence interval (CI): 0.94, 1.22), 1.04 (95% CI: 0.91, 1.18), and 1.04 (95% CI: 0.92, 1.17), respectively. Multivariable adjustments did not change the associations appreciably. Fasting status did not modify the associations, with the exception that SOD activity was positively associated with the risk of CHD among participants who provided blood samples within 12 hours of fasting. Overall, activities of SOD, GPx, and CAT were not associated with CHD among women who were generally healthy at the time of blood collection.
dc.language.isoen_US
dc.publisherOxford University Press
dash.licenseMETA_ONLY
dc.titleEditor's choice: Erythrocyte Superoxide Dismutase, Glutathione Peroxidase, and Catalase Activities and Risk of Coronary Heart Disease in Generally Healthy Women: A Prospective Study
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalAmerican Journal of Epidemiology
dash.depositing.authorRimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
dc.date.available2019-08-27T12:48:21Z
dash.workflow.comments1Science Serial ID 7795
dc.identifier.doi10.1093/aje/kwu195
dash.source.volume180;9
dash.source.page901


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