Intake of antioxidant vitamins and risk of Parkinson's disease
View/ Open
Author
Hughes, Katherine
Gao, Xiang
Kim, Iris
Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
Wang, Molin
Weisskopf, Marc
Schwarzschild, Michael
Ascherio, Alberto
Published Version
https://doi.org/10.1002/mds.26819Metadata
Show full item recordCitation
Hughes, Katherine C., Xiang Gao, Iris Y. Kim, Eric B. Rimm, Molin Wang, Marc G. Weisskopf, Michael A. Schwarzschild, and Alberto Ascherio. 2016. “Intake of Antioxidant Vitamins and Risk of Parkinson’s Disease.” Movement Disorders 31 (12): 1909–14. https://doi.org/10.1002/mds.26819.Abstract
Introduction: Oxidative stress is proposed to be one of the potential mechanisms leading to neurodegeneration in Parkinson's disease. However, previous epidemiologic studies investigating associations between antioxidant vitamins, such as vitamins E and C and carotenoids, and PD risk have produced inconsistent results. Objective: The objective of this work was to prospectively examine associations between intakes of antioxidant vitamins, including vitamins E and C and carotenoids, and PD risk. Methods: Cases were identified in two large cohorts: the Nurses' Health Study and the Health Professionals Follow-up Study. Cohort members completed semi-quantitative food frequency questionnaires every 4 years. Results: A total of 1036 PD cases were identified. Dietary intakes of vitamin E and carotenoids were not associated with PD risk; the multivariable-adjusted relative risk comparing extreme intake quintiles were 0.93 (95% confidence interval: 0.75-1.14) and 0.97 (95% confidence interval: 0.69-1.37), respectively. Dietary vitamin C intake was significantly associated with reduced PD risk (relative risk: 0.81; 95% confidence interval: 0.65-1.01; p(trend), 0.01); however, this result was not significant in a 4-year lag analysis. For vitamins E and C, intake from foods and supplements combined were also unrelated to PD risk. Conclusions: Our results do not support the hypothesis that intake of antioxidant vitamins reduces the risk of PD. (C) 2016 International Parkinson and Movement Disorder SocietyTerms of Use
This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAPCitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:41263027
Collections
- SPH Scholarly Articles [6387]
Contact administrator regarding this item (to report mistakes or request changes)