Alcohol consumption, TaqIB polymorphism of cholesteryl ester transfer protein, high-density lipoprotein cholesterol, and risk of coronary heart disease in men and women
Jensen, M. K.
Mukamal, K. J.
Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
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CitationJensen, M. K., K. J. Mukamal, K. Overvad, and E. B. Rimm. 2007. “Alcohol Consumption, TaqIB Polymorphism of Cholesteryl Ester Transfer Protein, High-Density Lipoprotein Cholesterol, and Risk of Coronary Heart Disease in Men and Women.” European Heart Journal 29 (1): 104–12. https://doi.org/10.1093/eurheartj/ehm517.
AbstractAims To investigate whether a common polymorphism in the cholesteryl ester transfer protein (CETP) gene modifies the relationship of alcohol intake with high-density lipoprotein cholesterol (HDL-C) and risk of coronary heart disease (CHD).Methods and results Parallel nested case-control studies among women [Nurses' Health Study (NHS)] and men [Health Professionals Follow-up Study (HPFS)] where 246 women and 259 men who developed incident CHD were matched to controls (1:2) on age and smoking. The TaqIB variant and alcohol consumption were associated with higher HDL-C, with the most pronounced effects of alcohol among B2 carriers. In the NHS we did not find an inverse association between alcohol and CHD in B2 non-carriers (P trend: 0.5), but did among B2 carriers (P trend < 0.01). Among non-carriers the odds ratio (OR) for CHD among women with an intake of 5-14 g/day was 1.4 (95% CI: 0.6-3.7) compared with non-drinkers, whereas among B2 carriers the OR was 0.4 (0.2-0.8). Results in men were less suggestive of an interaction; corresponding OR's were 1.9 (0.8-4.5) and 0.9 (0.5-1.6), for B2 non-carriers and carriers, respectively.Conclusions The association of alcohol with HDL-C levels was modified by CETP TaqIB2 carrier status, and there was also a suggestion of a gene-environment interaction on the risk of CHD.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41263050
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