Complement factor H (Y402H) polymorphism and risk of coronary heart disease in US men and women
Pai, J. K.
Manson, J. E.
Rexrode, K. M.
Albert, C. M.
Hunter, D. J.
Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
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CitationPai, J. K., J. E. Manson, K. M. Rexrode, C. M. Albert, D. J. Hunter, and E. B. Rimm. 2007. “Complement Factor H (Y402H) Polymorphism and Risk of Coronary Heart Disease in US Men and Women.” European Heart Journal 28 (11): 1297–1303. https://doi.org/10.1093/eurheartj/ehm090.
AbstractAims Complement factor H (CFH) Y402H polymorphism is located in a region that binds C-reactive protein and may affect inflammatory processes and risk of coronary heart disease (CHD). We assessed the association between Y402H and risk of CHD in nested case-controi studies among two large prospective cohorts of US mate health professionals and female nurses.Methods and results Among participants who were disease-free at baseline, we confirmed 266 (men) and 249 (women) incident CHD deaths and non-fatal myocardial infarctions (Mis) over 6 and 8 years of follow-up, respectively. Using risk-set sampling, controls were matched 2:1 on the basis of age, smoking, and date of blood draw. Comparing homozygous HH with Yy, the relative risk (RR) of CHD was 0.94 [95% confidence interval (CI) 0.59-1.49] among men and 0.51 (95% CI 0.29-0.89) among women (pooled RR 0.73, 95% CI 0.51-1.04). The HH genotype was inversely associated with CHD among those <65 years at onset (men: RR 0.39, 95% CI 0.16-0.95; women: 0.21, 95% CI 0.07-0.65; pooled: 0.30, 95% CI 0.15-0.61), but not among those >= 65 years (pooled RR 1.09, 95% CI 0.71-1.68).Conclusion CFH Y402H was inversely associated with CHD among women, but not men. This inverse association was observed in both populations with earlier age of CHD.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41263051
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