dc.contributor.author | Nan, Hongmei | |
dc.contributor.author | Xu, Mousheng | |
dc.contributor.author | Zhang, Jiangwen | |
dc.contributor.author | Zhang, Mingfeng | |
dc.contributor.author | Kraft, Peter | |
dc.contributor.author | Qureshi, Abrar A. | |
dc.contributor.author | Chen, Constance | |
dc.contributor.author | Guo, Qun | |
dc.contributor.author | Hu, Frank B. | |
dc.contributor.author | Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600 | |
dc.contributor.author | Curhan, Gary | |
dc.contributor.author | Song, Yiqing | |
dc.contributor.author | Amos, Christopher I. | |
dc.contributor.author | Wang, Li-E. | |
dc.contributor.author | Lee, Jeffrey E. | |
dc.contributor.author | Wei, Qingyi | |
dc.contributor.author | Hunter, David J. | |
dc.contributor.author | Han, Jiali | |
dc.date.accessioned | 2019-08-27T18:05:41Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Nan, Hongmei, Mousheng Xu, Jiangwen Zhang, Mingfeng Zhang, Peter Kraft, Abrar A. Qureshi, Constance Chen, et al. 2011. “Genome-Wide Association Study Identifies Nidogen 1 ( NID1 ) as a Susceptibility Locus to Cutaneous Nevi and Melanoma Risk.” Human Molecular Genetics 20 (13): 2673–79. https://doi.org/10.1093/hmg/ddr154. | |
dc.identifier.issn | 0964-6906 | |
dc.identifier.issn | 1460-2083 | |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:41263055 | * |
dc.description.abstract | We conducted a genome-wide association study on the number of melanocytic nevi reported by 9136 individuals of European ancestry, with follow-up replication in 3581 individuals. We identified the nidogen 1 (NID1) gene on 1q42 associated with nevus count (two linked single nucleotide polymorphisms with r(2) > 0.9: rs3768080 A allele associated with reduced count, P = 6.5 x 10(-8); and rs10754833 T allele associated with reduced count, P = 1.5 x 10(-7)). We further determined that the rs10754833 [T] was associated with a decreased melanoma risk in 2368 melanoma cases and 7432 controls [for CT genotype: odds ratio (OR) = 0.86, 95% confidence interval (CI) = 0.75-0.99, P = 0.04; for TT genotype: OR = 0.84, 95% CI = 0.71-0.98, P = 0.03]. Expression level of the NID1 locus was 2-fold higher for the rs10754833 T allele carriers than that with the CC genotype (P = 0.017) in the 87 HapMap CEU cell lines. The NID1 gene is a biologically plausible locus for nevogenesis and melanoma development, with decreased expression levels of NID1 in benign nevi (P = 3.5 x 10(-6)) and in primary melanoma (P = 4.6 x 10(-4)) compared with the normal skin. | |
dc.language.iso | en_US | |
dc.publisher | Oxford University Press | |
dash.license | META_ONLY | |
dc.title | Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk | |
dc.type | Journal Article | |
dc.description.version | Version of Record | |
dc.relation.journal | Human Molecular Genetics | |
dash.depositing.author | Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600 | |
dc.date.available | 2019-08-27T18:05:41Z | |
dash.workflow.comments | 1Science Serial ID 43758 | |
dc.identifier.doi | 10.1093/hmg/ddr154 | |
dash.source.volume | 20;13 | |
dash.source.page | 2673 | |