Using genetics to test the causal relationship of total adiposity and periodontitis: Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium
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Author
Shungin, Dmitry
Cornelis, Marilyn
Divaris, Kimon
Holtfreter, Birte
Shaffer, John
Yu, Yau-Hua
Barros, Silvana
Beck, James
Biffar, Reiner
Boerwinkle, Eric
Crout, Richard
Ganna, Andrea
Hallmans, Goran
Hindy, George
Hu, Frank
Kraft, Peter
McNeil, Daniel
Melander, Olle
Moss, Kevin
North, Kari
Orho-Melander, Marju
Pedersen, Nancy
Ridker, Paul
Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
Rose, Lynda
Rukh, Gull
Teumer, Alexander
Weyant, Robert
Chasman, Daniel
Joshipura, Kaumudi
Kocher, Thomas
Magnusson, Patrik K. E.
Marazita, Mary
Nilsson, Peter
Offenbacher, Steve
Smith, George Davey
Lundberg, Pernilla
Palmer, Tom
Timpson, Nicholas
Johansson, Ingegerd
Franks, Paul
Published Version
https://doi.org/10.1093/ije/dyv075Metadata
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Shungin, D., M. C. Cornelis, K. Divaris, B. Holtfreter, J. R. Shaffer, Y.-H. Yu, S. P. Barros, et al. 2015. “Using Genetics to Test the Causal Relationship of Total Adiposity and Periodontitis: Mendelian Randomization Analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium.” International Journal of Epidemiology 44 (2): 638–50. https://doi.org/10.1093/ije/dyv075.Abstract
Background: The observational relationship between obesity and periodontitis is widely known, yet causal evidence is lacking. Our objective was to investigate causal associations between periodontitis and body mass index (BMI). Methods: We performed Mendelian randomization analyses with BMI-associated loci combined in a genetic risk score (GRS) as the instrument for BMI. All analyses were conducted within the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium in 13 studies from Europe and the USA, including 49 066 participants with clinically assessed (seven studies, 42.1% of participants) and self-reported (six studies, 57.9% of participants) periodontitis and genotype data (17 672/31 394 with/without periodontitis); 68 761 participants with BMI and genotype data; and 57 871 participants (18 881/38 990 with/without periodontitis) with data on BMI and periodontitis. Results: In the observational meta-analysis of all participants, the pooled crude observational odds ratio (OR) for periodontitis was 1.13 [95% confidence interval (CI): 1.03, 1.24] per standard deviation increase of BMI. Controlling for potential confounders attenuated this estimate (OR = 1.08; 95% CI: 1.03, 1.12). For clinically assessed periodontitis, corresponding ORs were 1.25 (95% CI: 1.10, 1.42) and 1.13 (95% CI: 1.10, 1.17), respectively. In the genetic association meta-analysis, the OR for periodontitis was 1.01 (95% CI: 0.99, 1.03) per GRS unit (per one effect allele) in all participants and 1.00 (95% CI: 0.97, 1.03) in participants with clinically assessed periodontitis. The instrumental variable meta-analysis of all participants yielded an OR of 1.05 (95% CI: 0.80, 1.38) per BMI standard deviation, and 0.90 (95% CI: 0.56, 1.46) in participants with clinical data. Conclusions: Our study does not support total adiposity as a causal risk factor for periodontitis, as the point estimate is very close to the null in the causal inference analysis, with wide confidence intervals.Citable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:41263058
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