Association between alcohol consumption and plasma fetuin-A and its contribution to incident type 2 diabetes in women
Ley, Sylvia H.
Jimenez, Monik C.
Rexrode, Kathryn M.
Manson, JoAnn E.
Jensen, Majken K.
Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
Hu, Frank B.
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CitationLey, Sylvia H., Qi Sun, Monik C. Jimenez, Kathryn M. Rexrode, JoAnn E. Manson, Majken K. Jensen, Eric B. Rimm, and Frank B. Hu. 2013. “Association between Alcohol Consumption and Plasma Fetuin-A and Its Contribution to Incident Type 2 Diabetes in Women.” Diabetologia 57 (1): 93–101. https://doi.org/10.1007/s00125-013-3077-8.
AbstractAims/hypothesis The benefits of moderate alcohol consumption for type 2 diabetes have been postulated to involve a mechanism of improved insulin sensitivity. Fetuin-A, which is known to inhibit insulin signalling, has emerged as a biomarker for diabetes risk. Alcohol consumption may influence circulating fetuin-A concentrations and subsequently diabetes risk by altering the insulin signal. We therefore hypothesised that moderate alcohol consumption would be associated with lower fetuin-A concentration and that fetuin-A would partly explain the association between alcohol consumption and incident type 2 diabetes.Methods Among diabetes-free female participants in the Nurses' Health Study (n = 1,331), multiple linear regression was conducted to assess the association between alcohol consumption and plasma fetuin-A. Least-squares means (lsmeans) of fetuin-A were estimated in categories of alcohol consumption (0, 0.1-4.9, 5-14.9 and = 15 g/day). The proportion of alcohol consumption and diabetes association explained by baseline fetuin-A was assessed in 470 matched incident diabetes case-control pairs with follow-up 2000-2006.Results Higher alcohol consumption was associated with lower plasma fetuin-A (p for trend=0.009): lsmean +/- SE 476.5 +/- 5.9 mu g/ml for abstainers, 468.9 +/- 5.2 mu g/ml for 0.1-4.9 g/day consumers, 455.9 +/- 7.0 mu g/ml for 5.0-14.9 g/day consumers, and 450.0 +/- 9.4 mu g/ml for >= 15.0 g/day consumers. Fetuin-A and fasting insulin explained 18.4% and 54.8%, respectively, of the inverse association between alcohol consumption and diabetes after multiple adjustment (both p for contribution < 0.04).Conclusions/interpretation Moderate alcohol consumption is associated with lower plasma fetuin-A in diabetes-free women. Fetuin-A and insulin explain a significant proportion of the association between alcohol consumption and incident type 2 diabetes. Further studies are needed to examine potential biological mechanisms underlying this association.
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