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dc.contributor.authorSong, Mingyang
dc.contributor.authorGong, Jian
dc.contributor.authorGiovannucci, Edward
dc.contributor.authorBerndt, Sonja
dc.contributor.authorBrenner, Hermann
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorCurtis, Keith
dc.contributor.authorHarrison, Tabitha
dc.contributor.authorHoffmeister, Michael
dc.contributor.authorHsu, Li
dc.contributor.authorJiao, Shuo
dc.contributor.authorLe Marchand, Loic
dc.contributor.authorPotter, John
dc.contributor.authorSchoen, Robert
dc.contributor.authorSeminara, Daniela
dc.contributor.authorSlattery, Martha
dc.contributor.authorWhite, Emily
dc.contributor.authorWu, Kana
dc.contributor.authorOgino, Shuji
dc.contributor.authorFuchs, Charles
dc.contributor.authorHunter, David
dc.contributor.authorTworoger, Shelley
dc.contributor.authorHu, Frank
dc.contributor.authorRimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
dc.contributor.authorJensen, Majken
dc.contributor.authorPeters, Ulrike
dc.contributor.authorChan, Andrew
dc.date.accessioned2019-08-27T18:05:53Z
dc.date.issued2015
dc.identifier.citationSong, Mingyang, Jian Gong, Edward L. Giovannucci, Sonja I. Berndt, Hermann Brenner, Jenny Chang-Claude, Keith R. Curtis, et al. 2014. “Genetic Variants of Adiponectin and Risk of Colorectal Cancer.” International Journal of Cancer 137 (1): 154–64. https://doi.org/10.1002/ijc.29360.
dc.identifier.issn0020-7136
dc.identifier.issn1097-0215
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41263071*
dc.description.abstractCirculating adiponectin has been associated with lower risk of colorectal cancer (CRC). Genome-wide association studies have identified several single-nucleotide polymorphisms (SNPs) associated with adiponectin levels. However, it is unclear whether these SNPs are associated with CRC risk. In addition, previous data on SNPs in the adiponectin pathway and their associations with CRC are inconsistent. Therefore, we examined 19 SNPs in genes related to adiponectin or its receptors and their associations with CRC using logistic regression among 7,020 cases and 7,631 controls drawn from ten studies included in the Genetics and Epidemiology of Colorectal Cancer Consortium. Using data from a subset of two large cohort studies, we also assessed the contribution of individual SNPs and an adiponectin genetic score to plasma adiponectin after accounting for lifestyle factors among 2,217 women and 619 men. We did not find any statistically significant association between the 19 adiponectin-associated SNPs and CRC risk (multivariable-adjusted odds ratios ranged from 0.89 to 1.05, all p>0.05). Each SNP explained less than 2.50% of the variance of plasma adiponectin, and the genetic score collectively accounted for 2.95 and 1.42% of the variability of adiponectin in women and men, respectively, after adjustment for age, body mass index, physical activity, smoking, alcohol consumption, regular use of aspirin or nonsteroidal anti-inflammatory drug and postmenopausal hormone use. In conclusion, our findings do not support an association between known adiponectin-related common SNPs and CRC incidence. However, known common SNPs account for only a limited proportion of the interindividual variance in circulating adiponectin. Further work is warranted to investigate the relationship between adiponectin and CRC while accounting for other components in the pathway.What's new? Obesity is a well-established risk factor for colorectal cancer, and mounting evidence suggests that the adipocyte-derived hormone adiponectin is behind that link. In the present investigation, common genetic variants in the adiponectin (ADIPOQ) gene were analyzed for potential relationships with colorectal cancer risk. However, no statistically significant associations were identified. Because common genetic determinants account for only a limited proportion of the variance in circulating adiponectin concentrations, factors that influence adiponectin receptors and other components of the adiponectin pathway should be investigated.
dc.language.isoen_US
dc.publisherWiley
dash.licenseOAP
dc.titleGenetic variants of adiponectin and risk of colorectal cancer
dc.typeJournal Article
dc.description.versionAccepted Manuscript
dc.relation.journalInternational Journal of Cancer
dash.depositing.authorRimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
dc.date.available2019-08-27T18:05:53Z
dash.workflow.comments1Science Serial ID 41207
dc.identifier.doi10.1002/ijc.29360
dash.source.volume137;1
dash.source.page154


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