dc.contributor.author | Merchant, Anwar T. | |
dc.contributor.author | Hu, Frank B. | |
dc.contributor.author | Spiegelman, Donna | |
dc.contributor.author | Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600 | |
dc.contributor.author | Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600 | |
dc.contributor.author | Ascherio, Alberto | |
dc.date.accessioned | 2019-08-27T19:13:29Z | |
dc.date.issued | 2003 | |
dc.identifier.citation | Merchant, Anwar T., Frank B. Hu, Donna Spiegelman, Walter C. Willett, Eric B. Rimm, and Alberto Ascherio. 2003. “The Use of B Vitamin Supplements and Peripheral Arterial Disease Risk in Men Are Inversely Related.” The Journal of Nutrition 133 (9): 2863–67. https://doi.org/10.1093/jn/133.9.2863. | |
dc.identifier.issn | 0022-3166 | |
dc.identifier.issn | 1541-6100 | |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:41263095 | * |
dc.description.abstract | Peripheral arterial disease (PAD) causes morbidity and is associated with mortality. B vitamin intake has been inversely associated with coronary heart disease, but their effects on PAD are not known. We examined prospectively the relationships between dietary folate, vitamin B-6 and B-12 and PAD risk in 51,529 male U.S. health professionals, aged 40 to 75 y, who answered a detailed 131-item questionnaire to assess diet and vitamin supplement use. The study population consisted of 46,036 men free of PAD, cardiovascular disease and diabetes at baseline followed for 12 y during which we documented 308 incident PAD cases. For every 400 mug/d increment of folate intake, the multivariate adjusted PAD risk decreased by 21% [relative risk (RR) = 0.79, 95% Cl 0.64-0.96]. Men in the top category of folate intake (median = 840 mug) were at 33% lower risk of PAD than men in the bottom category (median = 244 mug) (RR = 0.67, 95% Cl 0.45-0.96, P-value, test for trend = 0.03) after multivariate adjustment. There were weak inverse associations between intake of vitamin B-6 and PAD risk (RR = 0.70, 95% Cl 0.48-1.02, P-value, test for trend = 0.06) and B-12 (RR = 0.77, 95% Cl 0.54-1.11, P-value, test for trend = 0.12). These results suggest that higher consumption of folate may contribute to the prevention of PAD. | |
dc.language.iso | en_US | |
dc.publisher | Oxford University Press | |
dash.license | META_ONLY | |
dc.title | The Use of B Vitamin Supplements and Peripheral Arterial Disease Risk in Men Are Inversely Related | |
dc.type | Journal Article | |
dc.description.version | Version of Record | |
dc.relation.journal | The Journal of Nutrition | |
dash.depositing.author | Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600 | |
dc.date.available | 2019-08-27T19:13:29Z | |
dash.workflow.comments | 1Science Serial ID 111880 | |
dc.identifier.doi | 10.1093/jn/133.9.2863 | |
dash.source.volume | 133;9 | |
dash.source.page | 2863-2867 | |