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dc.contributor.authorLemaitre, Rozenn
dc.contributor.authorKing, Irena
dc.contributor.authorKabagambe, Edmond
dc.contributor.authorWu, Jason
dc.contributor.authorMcKnight, Barbara
dc.contributor.authorManichaikul, Ani
dc.contributor.authorGuan, Weihua
dc.contributor.authorSun, Qi
dc.contributor.authorChasman, Daniel
dc.contributor.authorFoy, Millennia
dc.contributor.authorWang, Lu
dc.contributor.authorZhu, Jingwen
dc.contributor.authorSiscovick, David
dc.contributor.authorTsai, Michael
dc.contributor.authorArnett, Donna
dc.contributor.authorPsaty, Bruce
dc.contributor.authorDjousse, Luc
dc.contributor.authorChen, Yii-Der
dc.contributor.authorTang, Weihong
dc.contributor.authorWeng, Lu-Chen
dc.contributor.authorWu, Hongyu
dc.contributor.authorJensen, Majken
dc.contributor.authorChu, Audrey
dc.contributor.authorJacobs, David Jr.
dc.contributor.authorRich, Stephen
dc.contributor.authorMozaffarian, Dariush
dc.contributor.authorSteffen, Lyn
dc.contributor.authorRimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
dc.contributor.authorHu, Frank
dc.contributor.authorRidker, Paul
dc.contributor.authorFornage, Myriam
dc.contributor.authorFriedlander, Yechiel
dc.date.accessioned2019-08-27T19:13:31Z
dc.date.issued2015
dc.identifier.citationLemaitre, Rozenn N., Irena B. King, Edmond K. Kabagambe, Jason H. Y. Wu, Barbara McKnight, Ani Manichaikul, Weihua Guan, et al. 2014. “Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.” Journal of Lipid Research 56 (1): 176–84. https://doi.org/10.1194/jlr.m052456.
dc.identifier.issn0022-2275
dc.identifier.issn1539-7262
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41263098*
dc.description.abstractVery long-chain saturated fatty acids (VLSFAs) are saturated fatty acids with 20 or more carbons. In contrast to the more abundant saturated fatty acids, such as palmitic acid, there is growing evidence that circulating VLSFAs may have beneficial biological properties. Whether genetic factors influence circulating levels of VLSFAs is not known. We investigated the association of common genetic variation with plasma phospholipid/erythrocyte levels of three VLSFAs by performing genome-wide association studies in seven population-based cohorts comprising 10,129 subjects of European ancestry. We observed associations of circulating VLSFA concentrations with common variants in two genes, serine palmitoyl-transferase long-chain base subunit 3 (SPTLC3), a gene involved in the rate-limiting step of de novo sphingolipid synthesis, and ceramide synthase 4 (CERS4). The SPTLC3 variant at rs680379 was associated with higher arachidic acid (20:0, P = 5.81 x 10(-13)). The CERS4 variant at rs2100944 was associated with higher levels of 20:0 (P = 2.65 x 10(-40)) and in analyses that adjusted for 20:0, with lower levels of behenic acid (P = 4.22 x 10(-26)) and lignoceric acid (P = 3.20 x 10(-21)). These novel associations suggest an inter-relationship of circulating VLSFAs and sphingolipid synthesis.
dc.language.isoen_US
dash.licenseLAA
dc.titleGenetic loci associated with circulating levels of very long-chain saturated fatty acids
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalThe Journal of Lipid Research
dash.depositing.authorRimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
dc.date.available2019-08-27T19:13:31Z
dash.workflow.comments1Science Serial ID 110339
dc.identifier.doi10.1194/jlr.M052456
dash.source.volume56;1


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