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dc.contributor.authorSun, Qi
dc.contributor.authorWedick, Nicole
dc.contributor.authorTworoger, Shelley
dc.contributor.authorPan, An
dc.contributor.authorTownsend, Mary
dc.contributor.authorCassidy, Aedin
dc.contributor.authorFranke, Adrian
dc.contributor.authorRimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
dc.contributor.authorHu, Frank
dc.contributor.authorvan Dam, Rob M.
dc.date.accessioned2019-08-27T19:13:36Z
dc.date.issued2015
dc.identifier.citationSun, Qi, Nicole M Wedick, Shelley S Tworoger, An Pan, Mary K Townsend, Aedin Cassidy, Adrian A Franke, Eric B Rimm, Frank B Hu, and Rob M van Dam. 2015. “Urinary Excretion of Select Dietary Polyphenol Metabolites Is Associated with a Lower Risk of Type 2 Diabetes in Proximate but Not Remote Follow-Up in a Prospective Investigation in 2 Cohorts of US Women.” The Journal of Nutrition 145 (6): 1280–88. https://doi.org/10.3945/jn.114.208736.
dc.identifier.issn0022-3166
dc.identifier.issn1541-6100
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41263103*
dc.description.abstractBackground: Polyphenols are phytochemicals that possess antioxidant and anti-inflammatory properties and improve glucose metabolism in animal experiments, although data from prospective epidemiologic studies examining polyphenol intakes in relation to type 2 diabetes (T2D) risk are inconsistent. Objectives: We examined urinary excretion of select flavonoid and phenolic acid metabolites, as biomarkers of intake, in relation to T2D risk. Methods: Eight polyphenol metabolites (naringenin, hesperetin, quercetin, isorhamnetin, catechin, epicatechin, caffeic acid, and ferulic acid) were quantified in spot urine samples by liquid chromatography/mass spectrometry among 1111 T2D case-control pairs selected from the Nurses' Health Study (NHS) and NHSII. Results: Higher urinary excretion of hesperetin was associated with a lower T2D risk after multivariate adjustment: the OR comparing top vs. bottom quartiles was 0.68 (95% CI: 0.49, 0.96), although a linear trend was lacking (P = 0.30). The other measured polyphenols were not significantly associated with T2D risk after multivariate adjustment. However, during the early follow-up period [<= 4.6 y (median) since urine sample collection], markers of flavanone intakes (naringenin and hesperetin) and flavonol intakes (quercetin and isorhamnetin) were significantly associated with a lower T2D risk. The ORs (95% CIs) comparing extreme quartiles were 0.61 (0.39, 0.98; P-trend: 0.03) for total flavanones and 0.55 (0.33, 0.92; P-trend: 0.04) for total flavonols (P-interaction with follow-up length: <= 0.04). An inverse association was also observed for caffeic acid during early follow-up only: the OR was 0.52 195% CI: 0.32, 0.84; P-trend: 0.03). None of these markers was associated with T2D risk during later follow-up. Metabolites of flavan-3-ols and ferulic acid were not associated with T2D risk in either period. Conclusions: These results suggest that specific flavonoid subclasses, including flavanones and flavonols, as well as caffeic acid, are associated with a lower T2D risk in relatively short-term follow-up but not during longer follow-up. Substantial within-person variability of the metabolites in single spot urine samples may limit the ability to capture associations with long-term disease risk.
dc.language.isoen_US
dc.publisherOxford University Press
dash.licenseMETA_ONLY
dc.titleUrinary Excretion of Select Dietary Polyphenol Metabolites Is Associated with a Lower Risk of Type 2 Diabetes in Proximate but Not Remote Follow-Up in a Prospective Investigation in 2 Cohorts of US Women
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalThe Journal of Nutrition
dash.depositing.authorRimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
dc.date.available2019-08-27T19:13:36Z
dash.workflow.comments1Science Serial ID 116231
dc.identifier.doi10.3945/jn.114.208736
dash.source.volume145;6
dash.source.page1280


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