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dc.contributor.authorMcMullan, Ciaran J.
dc.contributor.authorSchernhammer, Eva S.
dc.contributor.authorRimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
dc.contributor.authorHu, Frank B.
dc.contributor.authorForman, John P.
dc.date.accessioned2019-08-27T19:13:37Z
dc.date.issued2013
dc.identifier.citationMcMullan, Ciaran J., Eva S. Schernhammer, Eric B. Rimm, Frank B. Hu, and John P. Forman. 2013. “Melatonin Secretion and the Incidence of Type 2 Diabetes.” JAMA 309 (13): 1388. https://doi.org/10.1001/jama.2013.2710.
dc.identifier.issn0098-7484
dc.identifier.issn1538-3598
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41263105*
dc.description.abstractImportance Loss-of-function mutations in the melatonin receptor are associated with insulin resistance and type 2 diabetes. Additionally, in a cross-sectional analysis of persons without diabetes, lower nocturnal melatonin secretion was associated with increased insulin resistance.Objective To study the association between melatonin secretion and the risk of developing type 2 diabetes.Design, Setting, and Participants Case-control study nested within the Nurses' Health Study cohort. Among participants without diabetes who provided urine and blood samples at baseline in 2000, we identified 370 women who developed type 2 diabetes from 2000-2012 and matched 370 controls using risk-set sampling.Main Outcome Measures Associations between melatonin secretion at baseline and incidence of type 2 diabetes were evaluated with multivariable conditional logistic regression controlling for demographic characteristics, lifestyle habits, measures of sleep quality, and biomarkers of inflammation and endothelial dysfunction.Results The median urinary ratios of 6-sulfatoxymelatonin to creatinine were 28.2 ng/mg (5%-95% range, 5.5-84.2 ng/mg) among cases and 36.3 ng/mg (5%-95% range, 6.9-110.8 ng/mg) among controls. Women with lower ratios of 6-sulfatoxymelatonin to creatinine had increased risk of diabetes (multivariable odds ratio, 1.48 [95% CI, 1.11-1.98] per unit decrease in the estimated log ratio of 6-sulfatoxymelatonin to creatinine). Compared with women in the highest ratio category of 6-sulfatoxymelatonin to creatinine, those in the lowest category had a multivariable odds ratio of 2.17 (95% CI, 1.18-3.98) of developing type 2 diabetes. Women in the highest category of melatonin secretion had an estimated diabetes incidence rate of 4.27 cases/1000 person-years compared with 9.27 cases/1000 person-years in the lowest category.Conclusions and Relevance Lower melatonin secretion was independently associated with a higher risk of developing type 2 diabetes. Further research is warranted to assess if melatonin secretion is a modifiable risk factor for diabetes within the general population. JAMA. 2013;309(13):1388-1396 www.jama.com
dc.language.isoen_US
dc.publisherAmerican Medical Association
dash.licenseOAP
dc.titleMelatonin secretion and the incidence of type 2 diabetes
dc.typeJournal Article
dc.description.versionAccepted Manuscript
dc.relation.journalJAMA - The Journal of the American Medical Association
dash.depositing.authorRimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
dc.date.available2019-08-27T19:13:37Z
dash.workflow.comments1Science Serial ID 49898
dc.identifier.doi10.1001/jama.2013.2710
dash.source.volume309;13
dash.source.page1388


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