Total and Cause-Specific Mortality of U.S. Nurses Working Rotating Night Shifts
Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600
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CitationGu, Fangyi, Jiali Han, Francine Laden, An Pan, Neil E. Caporaso, Meir J. Stampfer, Ichiro Kawachi, et al. 2015. “Total and Cause-Specific Mortality of U.S. Nurses Working Rotating Night Shifts.” American Journal of Preventive Medicine 48 (3): 241–52. https://doi.org/10.1016/j.amepre.2014.10.018.
AbstractBackground: Rotating night shift work imposes circadian strain and is linked to the risk of several chronic diseases.Purpose: To examine associations between rotating night shift work and all-cause; cardiovascular disease (CVD); and cancer mortality in a prospective cohort study of 74,862 registered U.S. nurses from the Nurses' Health Study. Methods: Lifetime rotating night shift work (defined as >= 3 nights/month) information was collected in 1988. During 22 years (1988-2010) of follow-up, 14,181 deaths were documented, including 3,062 CVD and 5,413 cancer deaths. Cox proportional hazards models estimated multivariable-adjusted hazard ratios (HRs) and 95% CIs. Results: All-cause and CVD mortality were significantly increased among women with >= 5 years of rotating night shift work, compared to women who never worked night shifts. Specifically, for women with 6-14 and >= 15 years of rotating night shift work, the HRs were 1.11 (95% CI=1.06, 1.17) and 1.11 (95% CI=1.05, 1.18) for all-cause mortality and 1.19 (95% CI=1.07, 1.33) and 1.23 (95% CI=1.09, 1.38) for CVD mortality. There was no significant association between rotating night shift work and all-cancer mortality (HR >= 15years=1.08, 95% CI=0.98, 1.19) or mortality of any individual cancer, with the exception of lung cancer (HR >= 15years=1.25, 95% CI=1.04, 1.51). Conclusions: Women working rotating night shifts for >= 5 years have a modest increase in all-cause and CVD mortality; those working >= 15 years of rotating night shift work have a modest increase in lung cancer mortality. These results add to prior evidence of a potentially detrimental effect of rotating night shift work on health and longevity.
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