Race-Related Health Disparities and Biological Aging: Does Rate of Telomere Shortening Differ Across Blacks and Whites?
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Author
Rewak, Marissa
Buka, Stephen
Prescott, Jennifer
De Vivo, Immaculata
Loucks, Eric
Kawachi, Ichiro
Non, Amy
Kubzansky, Laura
Published Version
https://doi.org/10.1016/j.biopsycho.2014.03.007Metadata
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Rewak, Marissa, Stephen Buka, Jennifer Prescott, Immaculata De Vivo, Eric B. Loucks, Ichiro Kawachi, Amy L. Non, and Laura D. Kubzansky. 2014. “Race-Related Health Disparities and Biological Aging: Does Rate of Telomere Shortening Differ across Blacks and Whites?” Biological Psychology 99 (May): 92–99. https://doi.org/10.1016/j.biopsycho.2014.03.007.Abstract
Recent work suggests that leukocyte telomere length (LTL), a marker of cellular aging, is sensitive to effects of social stress and may also provide early indication of premature aging. Using data from a birth cohort with LTL information at birth and in middle adulthood we examined a potential source of race-based health disparity by testing the hypothesis that Blacks would demonstrate a faster rate of telomere shortening than Whites. Linear regression analyses were conducted and adjusted for pack years, BMI, education and social factors, diet, exercise, marital status, and age. At birth black individuals had LTLs that were longer, on average, than their White counterparts (b = 3.85, p < 0.01). However, rate of shortening was greater for Blacks, who showed a larger difference in length between birth and adulthood (b = 5.10, p = 0.01) as compared with Whites, resulting in smaller racial differences in absolute adult LTL.Terms of Use
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http://nrs.harvard.edu/urn-3:HUL.InstRepos:41275527
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