dc.contributor.author | Marden, Jessica R. | |
dc.contributor.author | Walter, Stefan | |
dc.contributor.author | Tchetgen Tchetgen, Eric J. | |
dc.contributor.author | Kawachi, Ichiro | |
dc.contributor.author | Glymour, M. Maria | |
dc.date.accessioned | 2019-08-29T04:44:50Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Marden, Jessica R., Stefan Walter, Eric J. Tchetgen Tchetgen, Ichiro Kawachi, and M. Maria Glymour. 2014. “Validation of a Polygenic Risk Score for Dementia in Black and White Individuals.” Brain and Behavior 4 (5): 687–97. https://doi.org/10.1002/brb3.248. | |
dc.identifier.issn | 2045-8835 | |
dc.identifier.issn | 2162-3279 | |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:41275530 | * |
dc.description.abstract | Objective: To determine whether a polygenic risk score for Alzheimer's disease (AD) predicts dementia probability and memory functioning in non-Hispanic black (NHB) and non-Hispanic white (NHW) participants from a sample not used in previous genome-wide association studies. Methods: Non-Hispanic white and NHB Health and Retirement Study (HRS) participants provided genetic information and either a composite memory score (n = 10,401) or a dementia probability score (n = 7690). Dementia probability score was estimated for participants' age 65+ from 2006 to 2010, while memory score was available for participants age 50+. We calculated AD genetic risk scores (AD-GRS) based on 10 polymorphisms confirmed to predict AD, weighting alleles by beta coefficients reported in AlzGene meta-analyses. We used pooled logistic regression to estimate the association of the AD-GRS with dementia probability and generalized linear models to estimate its effect on memory score. Results: Each 0.10 unit change in the AD-GRS was associated with larger relative effects on dementia among NHW aged 65+ (OR = 2.22; 95% CI: 1.79, 2.74; P < 0.001) than NHB (OR = 1.33; 95% CI: 1.00, 1.77; P = 0.047), although additive effect estimates were similar. Each 0.10 unit change in the AD-GRS was associated with a -0.07 (95% CI: -0.09, -0.05; P < 0.001) SD difference in memory score among NHW aged 50+, but no significant differences among NHB (beta = -0.01; 95% CI: -0.04, 0.01; P = 0.546). [Correction added on 29 July 2014, after first online publication: confidence intervals have been amended.] The estimated effect of the GRS was significantly smaller among NHB than NHW (P < 0.05) for both outcomes. Conclusion: This analysis provides evidence for differential relative effects of the GRS on dementia probability and memory score among NHW and NHB in a new, national data set. | |
dc.language.iso | en_US | |
dc.publisher | | |
dash.license | LAA | |
dc.title | Validation of a polygenic risk score for dementia in black and white individuals | |
dc.type | Journal Article | |
dc.description.version | Version of Record | |
dc.relation.journal | Brain and Behavior | |
dash.depositing.author | Kawachi, Ichiro::3b17e788dad605ac69e3dd457b6c41ac::600 | |
dc.date.available | 2019-08-29T04:44:50Z | |
dash.workflow.comments | 1Science Serial ID 16258 | |
dc.identifier.doi | 10.1002/brb3.248 | |
dash.source.volume | 4;5 | |