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dc.contributor.authorJoshu, Corinne
dc.contributor.authorPeskoe, Sarah
dc.contributor.authorHeaphy, Christopher
dc.contributor.authorKenfield, Stacey
dc.contributor.authorVan Blarigan, Erin L.
dc.contributor.authorMucci, Lorelei
dc.contributor.authorGiovannucci, Edward
dc.contributor.authorStampfer, Meir
dc.contributor.authorYun, GhilSuk
dc.contributor.authorLee, Thomas
dc.contributor.authorHicks, Jessica
dc.contributor.authorDe Marzo, Angelo M.
dc.contributor.authorMeeker, Alan
dc.contributor.authorPlatz, Elizabeth
dc.date.accessioned2019-09-05T15:17:00Z
dc.date.issued2015
dc.identifier.citationJoshu, C. E., S. B. Peskoe, C. M. Heaphy, S. A. Kenfield, E. L. Van Blarigan, L. A. Mucci, E. L. Giovannucci, et al. 2015. “Prediagnostic Obesity and Physical Inactivity Are Associated with Shorter Telomere Length in Prostate Stromal Cells.” Cancer Prevention Research 8 (8): 737–42. https://doi.org/10.1158/1940-6207.capr-15-0097.
dc.identifier.issn1940-6207
dc.identifier.issn1940-6215
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41292450*
dc.description.abstractObesity and inactivity have been associated with advanced-stage prostate cancer, and poor prostate cancer outcomes, though the underlying mechanism(s) is unknown. To determine whether telomere shortening, which has been associated with lethal prostate cancer, may be a potential underlying mechanism, we prospectively evaluated the association between measures of adiposity, physical activity, and telomere length in 596 participants in the Health Professionals Follow-up Study, who were surgically treated for prostate cancer. Using tissue microarrays, we measured telomere length in cancer and benign cells using a telomere-specific FISH assay. Adiposity and activity were assessed via questionnaire within 2 years of diagnosis. Adjusting for age, pathologic stage, and grade, the median and SD of the per cell telomere signals were determined for each man for stromal cells and cancer cells by adiposity and activity categories. Overweight/obese men (54%) were similar to normal weight men on most factors, but had higher Gleason sum and lower activity levels. Overweight/obese men had 7.4% shorter telomeres in stromal cells than normal weight men (P = 0.06). The least active men had shorter telomeres in stromal cells than more active men (P-trend = 0.002). Men who were overweight/obese and the least active had the shortest telomeres in stromal cells (20.7% shorter; P = 0.0005) compared with normal weight men who were the most active. Cancer cell telomere length and telomere length variability did not differ by measures of adiposity or activity. Telomere shortening in prostate cells may be one mechanism through which lifestyle influences prostate cancer risk and outcomes.
dc.language.isoen_US
dc.publisherAmerican Association for Cancer Research
dash.licenseOAP
dc.titlePre-diagnostic obesity and physical inactivity are associated with shorter telomere length in prostate stromal cells
dc.typeJournal Article
dc.description.versionAccepted Manuscript
dc.relation.journalCancer Prevention Research (Philadelphia, Pa.)
dash.depositing.authorStampfer, Meir
dc.date.available2019-09-05T15:17:00Z
dash.workflow.comments1Science Serial ID 24369
dc.identifier.doi10.1158/1940-6207.CAPR-15-0097
dash.source.volume8;8
dash.source.page737
dash.contributor.affiliatedStampfer, Meir


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