Asthma and Risk of Lethal Prostate Cancer in the Health Professionals Follow-up Study
View/ Open
Author
Platz, Elizabeth
Drake, Charles
Wilson, Kathryn
Sutcliffe, Siobhan
Kenfield, Stacey
Mucci, Lorelei
Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600
Camargo, Carlos Jr.
Giovannucci, Edward
Published Version
https://doi.org/10.1002/ijc.29463Metadata
Show full item recordCitation
Platz, Elizabeth A., Charles G. Drake, Kathryn M. Wilson, Siobhan Sutcliffe, Stacey A. Kenfield, Lorelei A. Mucci, Meir J. Stampfer, Walter C. Willett, Carlos A. Camargo Jr, and Edward Giovannucci. 2015. “Asthma and Risk of Lethal Prostate Cancer in the Health Professionals Follow-Up Study.” International Journal of Cancer 137 (4): 949–58. https://doi.org/10.1002/ijc.29463.Abstract
Inflammation, and more generally, the immune response are thought to influence the development of prostate cancer. To determine the components of the immune response that are potentially contributory, we prospectively evaluated the association of immune-mediated conditions, asthma and hayfever, with lethal prostate cancer risk in the Health Professionals Follow-up Study. We included 47,880 men aged 40-75 years with no prior cancer diagnosis. On the baseline questionnaire in 1986, the men reported diagnoses of asthma and hayfever and year of onset. On the follow-up questionnaires, they reported new asthma and prostate cancer diagnoses. We used Cox proportional hazards regression to estimate relative risks (RRs). In total, 9.2% reported ever having been diagnosed with asthma. In all, 25.3% reported a hayfever diagnosis at baseline. During 995,176 person-years of follow-up by 2012, we confirmed 798 lethal prostate cancer cases (diagnosed with distant metastases, progressed to distant metastasis or died of prostate cancer [N = 625]). Ever having a diagnosis of asthma was inversely associated with risk of lethal (RR = 0.71, 95% confidence interval [CI] = 0.51-1.00) and fatal (RR = 0.64, 95% CI = 0.42-0.96) disease. Hayfever with onset in the distant past was possibly weakly positively associated with risk of lethal (RR = 1.10, 95% CI = 0.92-1.33) and fatal (RR = 1.12, 95% CI = 0.91-1.37) disease. Men who were ever diagnosed with asthma were less likely to develop lethal and fatal prostate cancer. Our findings may lead to testable hypotheses about specific immune profiles in the etiology of lethal prostate cancer.Terms of Use
This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAPCitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:41292467
Collections
- SPH Scholarly Articles [6329]
Contact administrator regarding this item (to report mistakes or request changes)