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dc.contributor.authorOng, Jue-Sheng
dc.contributor.authorCuellar-Partida, Gabriel
dc.contributor.authorLu, Yi
dc.contributor.authorFasching, Peter
dc.contributor.authorHein, Alexander
dc.contributor.authorBurghaus, Stefanie
dc.contributor.authorBeckmann, Matthias
dc.contributor.authorLambrechts, Diether
dc.contributor.authorVan Nieuwenhuysen, Els
dc.contributor.authorVergote, Ignace
dc.contributor.authorVanderstichele, Adriaan
dc.contributor.authorDoherty, Jennifer Anne
dc.contributor.authorRossing, Mary Anne
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorEilber, Ursula
dc.contributor.authorRudolph, Anja
dc.contributor.authorWang-Gohrke, Shan
dc.contributor.authorGoodman, Marc
dc.contributor.authorBogdanova, Natalia
dc.contributor.authorDörk, Thilo
dc.contributor.authorDürst, Matthias
dc.contributor.authorHillemanns, Peter
dc.contributor.authorRunnebaum, Ingo
dc.contributor.authorAntonenkova, Natalia
dc.contributor.authorButzow, Ralf
dc.contributor.authorLeminen, Arto
dc.contributor.authorNevanlinna, Heli
dc.contributor.authorPelttari, Liisa
dc.contributor.authorEdwards, Robert
dc.contributor.authorKelley, Joseph
dc.contributor.authorModugno, Francesmary
dc.contributor.authorMoysich, Kirsten
dc.contributor.authorNess, Roberta
dc.contributor.authorCannioto, Rikki
dc.contributor.authorHøgdall, Estrid
dc.contributor.authorHøgdall, Claus K.
dc.contributor.authorJensen, Allan
dc.contributor.authorGiles, Graham
dc.contributor.authorBruinsma, Fiona
dc.contributor.authorKjaer, Susanne
dc.contributor.authorHildebrandt, Michelle A. T.
dc.contributor.authorLiang, Dong
dc.contributor.authorLu, Karen
dc.contributor.authorWu, Xifeng
dc.contributor.authorBisogna, Maria
dc.contributor.authorDao, Fanny
dc.contributor.authorLevine, Douglas
dc.contributor.authorCramer, Daniel
dc.contributor.authorTerry, Kathryn
dc.contributor.authorTworoger, Shelley
dc.contributor.authorStampfer, Meir
dc.contributor.authorMissmer, Stacey
dc.contributor.authorBjorge, Line
dc.contributor.authorSalvesen, Helga
dc.contributor.authorKopperud, Reidun
dc.contributor.authorBischof, Katharina
dc.contributor.authorAben, Katja K. H.
dc.contributor.authorKiemeney, Lambertus
dc.contributor.authorMassuger, Leon F. A. G.
dc.contributor.authorBrooks-Wilson, Angela
dc.contributor.authorOlson, Sara
dc.contributor.authorMcGuire, Valerie
dc.contributor.authorRothstein, Joseph
dc.contributor.authorSieh, Weiva
dc.contributor.authorWhittemore, Alice
dc.contributor.authorCook, Linda
dc.contributor.authorLe, Nhu
dc.contributor.authorGilks, C. Blake
dc.contributor.authorGronwald, Jacek
dc.contributor.authorJakubowska, Anna
dc.contributor.authorLubiński, Jan
dc.contributor.authorKluz, Tomasz
dc.contributor.authorSong, Honglin
dc.contributor.authorTyrer, Jonathan
dc.contributor.authorWentzensen, Nicolas
dc.contributor.authorBrinton, Louise
dc.contributor.authorTrabert, Britton
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorMcLaughlin, John
dc.contributor.authorNarod, Steven
dc.contributor.authorPhelan, Catherine
dc.contributor.authorAnton-Culver, Hoda
dc.contributor.authorZiogas, Argyrios
dc.contributor.authorEccles, Diana
dc.contributor.authorCampbell, Ian
dc.contributor.authorGayther, Simon
dc.contributor.authorGentry-Maharaj, Aleksandra
dc.contributor.authorMenon, Usha
dc.contributor.authorRamus, Susan
dc.contributor.authorWu, Anna
dc.contributor.authorDansonka-Mieszkowska, Agnieszka
dc.contributor.authorKupryjanczyk, Jolanta
dc.contributor.authorTimorek, Agnieszka
dc.contributor.authorSzafron, Lukasz
dc.contributor.authorCunningham, Julie
dc.contributor.authorFridley, Brooke
dc.contributor.authorWinham, Stacey
dc.contributor.authorAustralian Ovarian Cancer Study
dc.date.accessioned2019-09-05T15:17:14Z
dc.date.issued2016
dc.identifier.citationOng, Jue-Sheng, Gabriel Cuellar-Partida, Yi Lu, Peter A Fasching, Alexander Hein, Stefanie Burghaus, Matthias W Beckmann, et al. 2016. “Association of Vitamin D Levels and Risk of Ovarian Cancer: A Mendelian Randomization Study.” International Journal of Epidemiology 45 (5): 1619–30. https://doi.org/10.1093/ije/dyw207.
dc.identifier.issn0300-5771
dc.identifier.issn1464-3685
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41292471*
dc.description.abstractBackground: In vitro and observational epidemiological studies suggest that vitamin D may play a role in cancer prevention. However, the relationship between vitamin D and ovarian cancer is uncertain, with observational studies generating conflicting findings. A potential limitation of observational studies is inadequate control of confounding. To overcome this problem, we used Mendelian randomization (MR) to evaluate the association between single nucleotide polymorphisms (SNPs) associated with circulating 25-hydroxyvitamin D [25(OH)D] concentration and risk of ovarian cancer. Methods: We employed SNPs with well-established associations with 25(OH) D concentration as instrumental variables for MR: rs7944926 (DHCR7), rs12794714 (CYP2R1) and rs2282679 (GC). We included 31 719 women of European ancestry (10 065 cases, 21 654 controls) from the Ovarian Cancer Association Consortium, who were genotyped using customized Illumina Infinium iSelect (iCOGS) arrays. A two-sample (summary data) MR approach was used and analyses were performed separately for all ovarian cancer (10 065 cases) and for high-grade serous ovarian cancer (4121 cases). Results: The odds ratio for epithelial ovarian cancer risk (10 065 cases) estimated by combining the individual SNP associations using inverse variance weighting was 1.27 (95% confidence interval: 1.06 to 1.51) per 20 nmol/L decrease in 25(OH) D concentration. The estimated odds ratio for high-grade serous epithelial ovarian cancer (4121 cases) was 1.54 (1.19, 2.01). Conclusions: Genetically lowered 25-hydroxyvitamin D concentrations were associated with higher ovarian cancer susceptibility in Europeans. These findings suggest that increasing plasma vitamin D levels may reduce risk of ovarian cancer.
dc.language.isoen_US
dc.publisherOxford University Press
dash.licenseMETA_ONLY
dc.titleAssociation of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalInternational Journal of Epidemiology
dash.depositing.authorStampfer, Meir
dc.date.available2019-09-05T15:17:14Z
dash.workflow.comments1Science Serial ID 43898
dc.identifier.doi10.1093/ije/dyw207
dash.source.volume45;5
dash.source.page1619
dash.contributor.affiliatedStampfer, Meir


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