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dc.contributor.authorAhearn, Thomas
dc.contributor.authorPettersson, Andreas
dc.contributor.authorEbot, Ericka
dc.contributor.authorGerke, Travis
dc.contributor.authorGraff, Rebecca
dc.contributor.authorMorais, Carlos
dc.contributor.authorHicks, Jessica
dc.contributor.authorWilson, Kathryn
dc.contributor.authorRider, Jennifer
dc.contributor.authorSesso, Howard
dc.contributor.authorFiorentino, Michelangelo
dc.contributor.authorFlavin, Richard
dc.contributor.authorFinn, Stephen
dc.contributor.authorGiovannucci, Edward
dc.contributor.authorLoda, Massimo
dc.contributor.authorStampfer, Meir
dc.contributor.authorDe Marzo, Angelo M.
dc.contributor.authorMucci, Lorelei
dc.contributor.authorLotan, Tamara
dc.date.accessioned2019-09-05T15:17:17Z
dc.date.issued2016
dc.identifier.citationAhearn, Thomas U., Andreas Pettersson, Ericka M. Ebot, Travis Gerke, Rebecca E. Graff, Carlos L. Morais, Jessica L. Hicks, et al. 2015. “A Prospective Investigation of PTEN Loss and ERG Expression in Lethal Prostate Cancer.” Journal of the National Cancer Institute 108 (2): djv346. https://doi.org/10.1093/jnci/djv346.
dc.identifier.issn0027-8874
dc.identifier.issn0198-0157
dc.identifier.issn1460-2105
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41292475*
dc.description.abstractBackground: PTEN is a tumor suppressor frequently deleted in prostate cancer that may be a useful prognostic biomarker. However, the association of PTEN loss with lethal disease has not been tested in a large, predominantly surgically treated cohort. Methods: In the Health Professionals Follow-up Study and Physicians' Health Study, we followed 1044 incident prostate cancer cases diagnosed between 1986 and 2009 for cancer-specific and all-cause mortality. A genetically validated PTEN immunohistochemistry (IHC) assay was performed on tissue microarrays (TMAs). TMPRSS2: ERG status was previously assessed in a subset of cases by a genetically validated IHC assay for ERG. Cox proportional hazards models adjusting for age and body mass index at diagnosis, Gleason grade, and clinical or pathologic TNM stage were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association with lethal disease. All statistical tests were two-sided. Results: On average, men were followed 11.7 years, during which there were 81 lethal events. Sixteen percent of cases had complete PTEN loss in all TMA cores and 9% had heterogeneous PTEN loss across cores. After adjustment for clinicalpathologic variables, complete PTEN loss was associated with lethal progression (HR = 1.8, 95% CI = 1.2 to 2.9). The association of PTEN loss (complete or heterogeneous) with lethal progression was only among men with ERG-negative (HR = 3.1, 95% CI = 1.7 to 5.7) but not ERG-positive (HR = 1.2, 95% CI = 0.7 to 2.2) tumors. Conclusions: PTEN loss is independently associated with increased risk of lethal progression, particularly in the ERG fusion-negative subgroup. These validated and inexpensive IHC assays may be useful for risk stratification in prostate cancer.
dc.language.isoen_US
dc.publisherOxford University Press
dash.licenseMETA_ONLY
dc.titleA Prospective Investigation of PTEN Loss and ERG Expression in Lethal Prostate Cancer
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalJournal of the National Cancer Institute
dash.depositing.authorStampfer, Meir
dc.date.available2019-09-05T15:17:17Z
dash.workflow.comments1Science Serial ID 61975
dc.identifier.doi10.1093/jnci/djv346
dash.source.volume108;2
dash.contributor.affiliatedStampfer, Meir


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