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dc.contributor.authorKey, Timothy
dc.contributor.authorAppleby, Paul
dc.contributor.authorTravis, Ruth
dc.contributor.authorAlbanes, Demetrius
dc.contributor.authorAlberg, Anthony
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorBlack, Amanda
dc.contributor.authorBoeing, Heiner
dc.contributor.authorBueno-de-Mesquita, H. Bas
dc.contributor.authorChan, June
dc.contributor.authorChen, Chu
dc.contributor.authorCook, Michael
dc.contributor.authorDonovan, Jenny
dc.contributor.authorGalan, Pilar
dc.contributor.authorGilbert, Rebecca
dc.contributor.authorGiles, Graham
dc.contributor.authorGiovannucci, Edward
dc.contributor.authorGoodman, Gary
dc.contributor.authorGoodman, Phyllis
dc.contributor.authorGunter, Marc
dc.contributor.authorHamdy, Freddie
dc.contributor.authorHeliövaara, Markku
dc.contributor.authorHelzlsouer, Kathy
dc.contributor.authorHenderson, Brian
dc.contributor.authorHercberg, Serge
dc.contributor.authorHoffman-Bolton, Judy
dc.contributor.authorHoover, Robert
dc.contributor.authorJohansson, Mattias
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorKing, Irena
dc.contributor.authorKnekt, Paul
dc.contributor.authorKolonel, Laurence
dc.contributor.authorLe Marchand, Loic
dc.contributor.authorMännistö, Satu
dc.contributor.authorMartin, Richard
dc.contributor.authorMeyer, Haakon
dc.contributor.authorMondul, Alison
dc.contributor.authorMoy, Kristin
dc.contributor.authorNeal, David
dc.contributor.authorNeuhouser, Marian
dc.contributor.authorPalli, Domenico
dc.contributor.authorPlatz, Elizabeth
dc.contributor.authorPouchieu, Camille
dc.contributor.authorRissanen, Harri
dc.contributor.authorSchenk, Jeannette
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorStampfer, Meir
dc.contributor.authorTjønneland, Anne
dc.contributor.authorTouvier, Mathilde
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorWeinstein, Stephanie
dc.contributor.authorZiegler, Regina
dc.contributor.authorZhou, Cindy Ke
dc.contributor.authorAllen, Naomi
dc.date.accessioned2019-09-05T15:17:20Z
dc.date.issued2015
dc.identifier.citationKey, Timothy J, Paul N Appleby, Ruth C Travis, Demetrius Albanes, Anthony J Alberg, Aurelio Barricarte, Amanda Black, et al. 2015. “Carotenoids, Retinol, Tocopherols, and Prostate Cancer Risk: Pooled Analysis of 15 Studies.” The American Journal of Clinical Nutrition 102 (5): 1142–57. https://doi.org/10.3945/ajcn.115.114306.
dc.identifier.issn0002-9165
dc.identifier.issn1938-3207
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41292479*
dc.description.abstractBackground: Individual studies have suggested that circulating carotenoids, retinol, or tocopherols may be associated with prostate cancer risk, but the studies have not been large enough to provide precise estimates of associations, particularly by stage and grade of disease. Objective: The objective of this study was to conduct a pooled analysis of the associations of the concentrations of 7 carotenoids, retinol, alpha-tocopherol, and gamma-tocopherol with risk of prostate cancer and to describe whether any associations differ by stage or grade of the disease or other factors. Design: Principal investigators of prospective studies provided individual participant data for prostate cancer cases and controls. Risk by study-specific fifths of each biomarker was estimated by using multivariable-adjusted conditional logistic regression in matched case-control sets. Results: Data were available for up to 11,239 cases (including 1654 advanced stage and 1741 aggressive) and 18,541 controls from 15 studies. Lycopene was not associated with overall risk of prostate cancer, but there was statistically significant heterogeneity by stage of disease, and the OR for aggressive disease for the highest compared with the lowest fifth of lycopene was 0.65 (95% CI: 0.46, 0.91; P-trend = 0.032). No other carotenoid was significantly associated with overall risk of prostate cancer or with risk of advanced-stage or aggressive disease. For retinol, the OR for the highest compared with the lowest fifth was 1.13 (95% CI: 1.04, 1.22; P-trend = 0.015). For alpha-tocopherol, the OR for the highest compared with the lowest fifth was 0.86 (95% CI: 0.78, 0.94; P-trend < 0.001), with significant heterogeneity by stage of disease; the OR for aggressive prostate cancer was 0.74 (95% CI: 0.59, 0.92; P-trend = 0.001). gamma-Tocopherol was not associated with risk. Conclusions: Overall prostate cancer risk was positively associated with retinol and inversely associated with alpha-tocopherol, and risk of aggressive prostate cancer was inversely associated with lycopene and alpha-tocopherol. Whether these associations reflect causal relations is unclear.
dc.language.isoen_US
dc.publisherOxford University Press
dash.licenseMETA_ONLY
dc.titleCarotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalAmerican Journal of Clinical Nutrition
dash.depositing.authorStampfer, Meir
dc.date.available2019-09-05T15:17:20Z
dash.workflow.comments1Science Serial ID 7212
dc.identifier.doi10.3945/ajcn.115.114306
dash.source.volume102;5
dash.source.page1142
dash.contributor.affiliatedStampfer, Meir


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