dc.contributor.author | Pettersson, Andreas | |
dc.contributor.author | Graff, Rebecca E. | |
dc.contributor.author | Bauer, Scott R. | |
dc.contributor.author | Pitt, Michael | |
dc.contributor.author | Lis, Rosina T. | |
dc.contributor.author | Stack, Edward C. | |
dc.contributor.author | Martin, Neil E. | |
dc.contributor.author | Kunz, Lauren | |
dc.contributor.author | Penney, Kathryn L. | |
dc.contributor.author | Ligon, Azra H. | |
dc.contributor.author | Suppan, Catherine | |
dc.contributor.author | Flavin, Richard | |
dc.contributor.author | Sesso, Howard D. | |
dc.contributor.author | Rider, Jennifer R. | |
dc.contributor.author | Sweeney, Christopher | |
dc.contributor.author | Stampfer, Meir | |
dc.contributor.author | Fiorentino, Michelangelo | |
dc.contributor.author | Kantoff, Philip W. | |
dc.contributor.author | Sanda, Martin | |
dc.contributor.author | Giovannucci, Edward | |
dc.contributor.author | Ding, Eric L. | |
dc.contributor.author | Loda, Massimo | |
dc.contributor.author | Mucci, Lorelei A. | |
dc.date.accessioned | 2019-09-05T17:04:04Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Pettersson, A., R. E. Graff, S. R. Bauer, M. J. Pitt, R. T. Lis, E. C. Stack, N. E. Martin, et al. 2012. “The TMPRSS2:ERG Rearrangement, ERG Expression, and Prostate Cancer Outcomes: A Cohort Study and Meta-Analysis.” Cancer Epidemiology Biomarkers & Prevention 21 (9): 1497–1509. https://doi.org/10.1158/1055-9965.epi-12-0042. | |
dc.identifier.issn | 1055-9965 | |
dc.identifier.issn | 1538-7755 | |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:41292505 | * |
dc.description.abstract | Background: Whether the genomic rearrangement transmembrane protease, serine 2 (TMPRSS2):v-ets erythroblastosis virus E26 oncogene homolog (ERG) has prognostic value in prostate cancer is unclear. Methods: Among men with prostate cancer in the prospective Physicians' Health and Health Professionals Follow-Up Studies, we identified rearrangement status by immunohistochemical assessment of ERG protein expression. We used Cox models to examine associations of ERG overexpression with biochemical recurrence and lethal disease (distant metastases or cancer-specific mortality). In a meta-analysis including 47 additional studies, we used random-effects models to estimate associations between rearrangement status and outcomes. Results: The cohort consisted of 1,180 men treated with radical prostatectomy between 1983 and 2005. During a median follow-up of 12.6 years, 266 men experienced recurrence and 85 men developed lethal disease. We found no significant association between ERG overexpression and biochemical recurrence [hazard ratio (HR), 0.99; 95% confidence interval (CI), 0.78-1.26] or lethal disease (HR, 0.93; 95% CI, 0.61-1.43). The meta-analysis of prostatectomy series included 5,074 men followed for biochemical recurrence (1,623 events), and 2,049 men followed for lethal disease (131 events). TMPRSS2: ERG was associated with stage at diagnosis [ risk ratio (RR)(>T3 vs. T2), 1.23; 95% CI, 1.16-1.30) but not with biochemical recurrence (RR, 1.00; 95% CI, 0.86-1.17) or lethal disease (RR, 0.99; 95% CI, 0.47-2.09). Conclusions: These results suggest that TMPRSS2: ERG, or ERG overexpression, is associated with tumor stage but does not strongly predict recurrence or mortality among men treated with radical prostatectomy.Impact: This is the largest prospective cohort study to examine associations of ERG overexpression and lethal prostate cancer among men treated with radical prostatectomy. Cancer Epidemiol Biomarkers Prev; 21(9); 1497-509. | |
dc.language.iso | en_US | |
dc.publisher | American Association for Cancer Research | |
dash.license | LAA | |
dc.title | The Tmprss2:erg Rearrangement, Erg Expression, and Prostate Cancer Outcomes: A Cohort Study and Meta-analysis | |
dc.type | Journal Article | |
dc.description.version | Accepted Manuscript | |
dc.relation.journal | Cancer Epidemiology, Biomarkers & Prevention | |
dash.depositing.author | Stampfer, Meir | |
dc.date.available | 2019-09-05T17:04:04Z | |
dash.workflow.comments | 1Science Serial ID 26792 | |
dc.identifier.doi | 10.1158/1055-9965.EPI-12-0042 | |
dash.source.volume | 21;9 | |
dash.source.page | 1497 | |
dash.contributor.affiliated | Stampfer, Meir | |