Body Size and Multiple Myeloma Mortality: a pooled analysis of 20 prospective studies
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Author
Teras, Lauren
Kitahara, Cari
Birmann, Brenda
Hartge, Patricia
Wang, Sophia
Robien, Kim
Patel, Alpa
Adami, Hans-Olov
Weiderpass, Elisabete
Giles, Graham
Singh, Pramil
Alavanja, Michael
Freeman, Laura E. Beane
Bernstein, Leslie
Buring, Julie
Colditz, Graham
Fraser, Gary
Gapstur, Susan
Gaziano, J. Michael
Giovannucci, Edward
Hofmann, Jonathan
Linet, Martha
Neta, Gila
Park, Yikyung
Peters, Ulrike
Rosenberg, Philip
Schairer, Catherine
Sesso, Howard
Visvanathan, Kala
White, Emily
Wolk, Alicja
Zeleniuch-Jacquotte, Anne
de González, Amy Berrington
Purdue, Mark
Published Version
https://doi.org/10.1111/bjh.12935Metadata
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Teras, Lauren R., Cari M. Kitahara, Brenda M. Birmann, Patricia A. Hartge, Sophia S. Wang, Kim Robien, Alpa V. Patel, et al. 2014. “Body Size and Multiple Myeloma Mortality: A Pooled Analysis of 20 Prospective Studies.” British Journal of Haematology 166 (5): 667–76. https://doi.org/10.1111/bjh.12935.Abstract
Multiple myeloma (MM) is a rare but highly fatal malignancy. High body weight is associated with this cancer, but several questions remain regarding the aetiological relevance of timing and location of body weight. To address these questions, we conducted a pooled analysis of MM mortality using 1.5 million participants (including 1388 MM deaths) from 20 prospective cohorts in the National Cancer Institute Cohort Consortium. Proportional hazards regression was used to calculate pooled multivariate hazard ratios (HRs) and 95% confidence intervals (CIs). Associations with elevated MM mortality were observed for higher early-adult body mass index (BMI; HR = 1.22, 95% CI: 1.09-1.35 per 5 kg/m(2)) and for higher cohort-entry BMI (HR 1.09, 95% CI: 1.03-1.16 per 5 kg/m(2)) and waist circumference (HR = 1.06, 95% CI: 1.02-1.10 per 5 cm). In analyses of the joint effect of young adult and baseline BMI, women who were the heaviest, both in early adulthood (BMI 25+) and at cohort entry (BMI 30+) were at greater risk compared to those with BMI 18.5 = 25 at both time points (HR = 1.95, 95% CI: 1.33-2.86) but there was no significant association in men. Waist-to-hip ratio and height were not associated with MM mortality. These observations suggest that overall, and possibly also central, obesity influence myeloma mortality, and women have the highest risk of death from this cancer if they remain heavy throughout adulthood.Terms of Use
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http://nrs.harvard.edu/urn-3:HUL.InstRepos:41292526
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