Seasonal variation in expression of markers in the vitamin D pathway in prostate tissue
View/ Open
Author
Epstein, Mara Meyer
Andrén, Ove
Kasperzyk, Julie L.
Shui, Irene M.
Penney, Kathryn L.
Fall, Katja
Rider, Jennifer R.
Andersson, Swen-Olof
Giovannucci, Edward
Mucci, Lorelei A.
Published Version
https://doi.org/10.1007/s10552-012-0016-9Metadata
Show full item recordCitation
Epstein, Mara M., Ove Andrén, Julie L. Kasperzyk, Irene M. Shui, Kathryn L. Penney, Katja Fall, Jennifer R. Rider, et al. 2012. “Seasonal Variation in Expression of Markers in the Vitamin D Pathway in Prostate Tissue.” Cancer Causes & Control 23 (8): 1359–66. https://doi.org/10.1007/s10552-012-0016-9.Abstract
Recent studies suggest variation in genes along the vitamin D pathway, as well as vitamin D receptor (VDR) protein levels, may be associated with prostate cancer. As serum vitamin D levels vary by season, we sought to determine whether the expression of genes on the vitamin D pathway, assessed in prostate tumor tissue, do the same.Our study incorporates mRNA expression data from 362 men in the Swedish Watchful Waiting cohort, diagnosed between 1977 and 1999, and 106 men enrolled in the US Physicians' Health Study (PHS) diagnosed between 1983 and 2004. We also assayed for VDR protein expression among 832 men in the PHS and Health Professionals Follow-up Study cohorts. Season was characterized by date of initial tissue specimen collection categorically and by average monthly ultraviolet radiation levels. One-way analysis of variance was used to examine variation in the expression levels of six genes on the vitamin D pathway-VDR, GC, CYP27A1, CYP27B1, RXR alpha, CYP24A1-and VDR protein by season, adjusted for age at diagnosis and Gleason grade. Variation was also examined separately among lethal and nonlethal cases.Tumor expression levels of the six genes did not vary significantly by season of tissue collection. No consistent patterns emerged from subgroup analyses by lethal versus nonlethal cases.Unlike circulating levels of 25(OH) vitamin D, expression levels of genes on the vitamin D pathway and VDR protein did not vary overall by season of tissue collection. Epidemiological analyses of vitamin D gene expression may not be biased by seasonality.Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:41292541
Collections
- SPH Scholarly Articles [6311]
Contact administrator regarding this item (to report mistakes or request changes)