The Association of Antioxidants and Cognition in the Nurses’ Health Study
Devore, Elizabeth E.
Kang, Jae H.
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CitationDevore, E. E., J. H. Kang, M. J. Stampfer, and F. Grodstein. 2012. “The Association of Antioxidants and Cognition in the Nurses’ Health Study.” American Journal of Epidemiology 177 (1): 33–41. https://doi.org/10.1093/aje/kws202.
AbstractThe authors examined long-term antioxidant intake in relation to cognitive decline among older women. Beginning in 1980, Nurses' Health Study (NHS) participants completed dietary assessments every 4 years; in 19952001, 16,010 participants aged epsilon 70 years completed initial cognitive assessments, which were repeated 3 times at 2-year intervals. Long-term antioxidant intake was averaged from 1980 through the time of initial cognitive interviews. Multivariable-adjusted linear regression was used to estimate mean differences in rates of cognitive decline across categories of vitamin E, vitamin C, and carotenoid intake; statistical tests were 2-sided. No associations were evident for vitamin E or total carotenoid intake and cognitive decline (e.g., after multivariable adjustment, P-trend 0.44 and P-trend 0.51, respectively, for a global composite score averaging all 6 cognitive tests), although higher lycopene intake and lower vitamin C intake were related to slower cognitive decline. In alternative analyses of overall cognitive status at older ages (averaging all 4 cognitive assessments), results for vitamins E and C were generally null, but higher carotenoid intake was related to better cognition. Overall, long-term vitamin E and C intakes were not consistently related to cognition, although greater consumption of carotenoids may have cognitive benefits in older adults.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41292543
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