dc.contributor.author | Park, Yikyung | |
dc.contributor.author | Spiegelman, Donna | |
dc.contributor.author | Hunter, David J. | |
dc.contributor.author | Albanes, Demetrius | |
dc.contributor.author | Bergkvist, Leif | |
dc.contributor.author | Buring, Julie E. | |
dc.contributor.author | Freudenheim, Jo L. | |
dc.contributor.author | Giovannucci, Edward | |
dc.contributor.author | Goldbohm, R. Alexandra | |
dc.contributor.author | Harnack, Lisa | |
dc.contributor.author | Kato, Ikuko | |
dc.contributor.author | Krogh, Vittorio | |
dc.contributor.author | Leitzmann, Michael F. | |
dc.contributor.author | Limburg, Paul J. | |
dc.contributor.author | Marshall, James R. | |
dc.contributor.author | McCullough, Marjorie L. | |
dc.contributor.author | Miller, Anthony B. | |
dc.contributor.author | Rohan, Thomas E. | |
dc.contributor.author | Schatzkin, Arthur | |
dc.contributor.author | Shore, Roy | |
dc.contributor.author | Sieri, Sabina | |
dc.contributor.author | Stampfer, Meir | |
dc.contributor.author | Virtamo, Jarmo | |
dc.contributor.author | Weijenberg, Matty | |
dc.contributor.author | Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600 | |
dc.contributor.author | Wolk, Alicja | |
dc.contributor.author | Zhang, Shumin M. | |
dc.contributor.author | Smith-Warner, Stephanie A. | |
dc.date.accessioned | 2019-09-05T18:09:03Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | Park, Yikyung, Donna Spiegelman, David J. Hunter, Demetrius Albanes, Leif Bergkvist, Julie E. Buring, Jo L. Freudenheim, et al. 2010. “Intakes of Vitamins A, C, and E and Use of Multiple Vitamin Supplements and Risk of Colon Cancer: A Pooled Analysis of Prospective Cohort Studies.” Cancer Causes & Control 21 (11): 1745–57. https://doi.org/10.1007/s10552-010-9549-y. | |
dc.identifier.issn | 0957-5243 | |
dc.identifier.issn | 1573-7225 | |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:41292560 | * |
dc.description.abstract | To evaluate the associations between intakes of vitamins A, C, and E and risk of colon cancer.Using the primary data from 13 cohort studies, we estimated study- and sex-specific relative risks (RR) with Cox proportional hazards models and subsequently pooled RRs using a random effects model.Among 676,141 men and women, 5,454 colon cancer cases were identified (7-20 years of follow-up across studies). Vitamin A, C, and E intakes from food only were not associated with colon cancer risk. For intakes from food and supplements (total), the pooled multivariate RRs (95% CI) were 0.88 (0.76-1.02, > 4,000 vs. a parts per thousand currency sign1,000 mu g/day) for vitamin A, 0.81 (0.71-0.92, > 600 vs. a parts per thousand currency sign100 mg/day) for vitamin C, and 0.78 (0.66-0.92, > 200 vs. a parts per thousand currency sign6 mg/day) for vitamin E. Adjustment for total folate intake attenuated these associations, but the inverse associations with vitamins C and E remained significant. Multivitamin use was significantly inversely associated with colon cancer risk (RR = 0.88, 95% CI: 0.81-0.96).Modest inverse associations with vitamin C and E intakes may be due to high correlations with folate intake, which had a similar inverse association with colon cancer. An inverse association with multivitamin use, a major source of folate and other vitamins, deserves further study. | |
dc.language.iso | en_US | |
dc.publisher | Springer (part of Springer Nature) | |
dash.license | LAA | |
dc.title | Intakes of vitamins A, C, and E and use of multiple vitamin supplements and risk of colon cancer: a pooled analysis of prospective cohort studies | |
dc.type | Journal Article | |
dc.description.version | Accepted Manuscript | |
dc.relation.journal | Cancer Causes and Control | |
dash.depositing.author | Stampfer, Meir | |
dc.date.available | 2019-09-05T18:09:03Z | |
dash.workflow.comments | 1Science Serial ID 22807 | |
dc.identifier.doi | 10.1007/s10552-010-9549-y | |
dash.source.volume | 21;11 | |
dash.source.page | 1745 | |
dash.contributor.affiliated | Stampfer, Meir | |