Circulating levels of vitamin D and colon and rectal cancer: the Physicians’ Health Study and a meta-analysis of prospective studies
Lee, Jung Eun
Chan, Andrew T.
Hollis, Bruce W.
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CitationLee, J. E., H. Li, A. T. Chan, B. W. Hollis, I.-M. Lee, M. J. Stampfer, K. Wu, E. Giovannucci, and J. Ma. 2011. “Circulating Levels of Vitamin D and Colon and Rectal Cancer: The Physicians’ Health Study and a Meta-Analysis of Prospective Studies.” Cancer Prevention Research 4 (5): 735–43. https://doi.org/10.1158/1940-6207.capr-10-0289.
AbstractIt remains unknown whether increased risk with low levels of vitamin D is present for colon and/or rectal cancer. To investigate the association between circulating vitamin D levels and colon and rectal cancer, we examined the associations between plasma levels of 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)2D] and colon and rectal cancer in the Physicians' Health Study and then conducted a meta-analysis of eight prospective studies of circulating levels of 25(OH)D and colon and rectal cancers, including the Physicians' Health Study. Study-specific ORs and 95% CIs were pooled by using a random-effects model. A total of 1,822 colon and 868 rectal cancers were included in the meta-analysis. We observed a significant inverse association for colorectal cancer (OR = 0.66; 95% Cl, 0.54-0.81), comparing top versus bottom quantiles of circulating 25(OH)D levels. The inverse association stronger for rectal cancer (OR = 0.50 for top versus bottom quantiles; 95% CI, 0.28-0.88) than colon cancer (OR = 0.77; 95% CI, 0.56-1.07; P value for difference between colon and rectal cancer = 0.20). These data suggest an inverse association between circulating 25(OH)D levels and colorectal cancer, with a stronger association for rectal cancer. Cancer Pier Res; 4(5); 735-43.
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