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dc.contributor.authorTravis, Ruth C.
dc.contributor.authorSchumacher, Fredrick
dc.contributor.authorHirschhorn, Joel N.
dc.contributor.authorKraft, Peter
dc.contributor.authorAllen, Naomi E.
dc.contributor.authorAlbanes, Demetrius
dc.contributor.authorBerglund, Goran
dc.contributor.authorBerndt, Sonja I.
dc.contributor.authorBoeing, Heiner
dc.contributor.authorBueno-de-Mesquita, H. Bas
dc.contributor.authorCalle, Eugenia E.
dc.contributor.authorChanock, Stephen
dc.contributor.authorDunning, Alison M.
dc.contributor.authorHayes, Richard
dc.contributor.authorFeigelson, Heather Spencer
dc.contributor.authorGaziano, J. Michael
dc.contributor.authorGiovannucci, Edward
dc.contributor.authorHaiman, Christopher A.
dc.contributor.authorHenderson, Brian E.
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorKolonel, Laurence N.
dc.contributor.authorMa, Jing
dc.contributor.authorRodriguez, Laudina
dc.contributor.authorRiboli, Elio
dc.contributor.authorStampfer, Meir
dc.contributor.authorStram, Daniel O.
dc.contributor.authorThun, Michael J.
dc.contributor.authorTjønneland, Anne
dc.contributor.authorTrichopoulos, Dimitrios
dc.contributor.authorVineis, Paolo
dc.contributor.authorVirtamo, Jarmo
dc.contributor.authorMarchand, Loïc Le
dc.contributor.authorHunter, David J.
dc.date.accessioned2019-09-06T14:15:26Z
dc.date.issued2009
dc.identifier.citationTravis, R. C., F. Schumacher, J. N. Hirschhorn, P. Kraft, N. E. Allen, D. Albanes, G. Berglund, et al. 2009. “CYP19A1 Genetic Variation in Relation to Prostate Cancer Risk and Circulating Sex Hormone Concentrations in Men from the Breast and Prostate Cancer Cohort Consortium.” Cancer Epidemiology Biomarkers & Prevention 18 (10): 2734–44. https://doi.org/10.1158/1055-9965.epi-09-0496.
dc.identifier.issn1055-9965
dc.identifier.issn1538-7755
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41292879*
dc.description.abstractSex hormones, particularly the androgens, are important for the growth of the prostate gland and have been implicated in prostate cancer carcinogenesis, yet the determinants of endogenous steroid hormone levels remain poorly understood. Twin studies suggest a heritable component for circulating concentrations of sex hormones, although epidemiologic evidence linking steroid hormone gene variants to prostate cancer is limited. Here we report on findings from a comprehensive study of genetic variation at the CYP19A1 locus in relation to prostate cancer risk and to circulating steroid hormone concentrations in men by the Breast and Prostate Cancer Cohort Consortium (BPC3), a large collaborative prospective study. The BPC3 systematically characterized variation in CYP19A1 by targeted resequencing and dense genotyping; selected haplotype-tagging single nuclecitide polymorphisms (htSNP) that efficiently predict common variants in U.S. and Europe-an whites, Latinos, Japanese Americans, and Native Hawaiians; and genotyped these htSNPs; in 8,166 prostate cancer cases and 9,079 study-, age-, and ethnicity-matched controls. CYP19A1 htSNPs, two common missense variants and common haplotypes were not significantly associated with risk of prostate cancer. However, several htSNPs in linkage disequilibrium blocks 3 and 4 were significantly associated with a 5% to 10% difference in estradiol concentrations in men [association per copy of the two-SNP haplotype rs749292-rs727479 (A-A) versus noncarriers; P = 1 x 10(-5)], and with inverse, although less marked changes, in free testosterone concentrations. These results suggest that although germline variation in CYP19A1 characterized by the htSNPs produces measurable differences in sex hormone concentrations in men, they do not substantially influence risk of prostate cancer. (Cancer Epidemiol Biomarkers Prev 2009;18(10):2734-44)
dc.language.isoen_US
dc.publisherAmerican Association for Cancer Research
dash.licenseLAA
dc.titleCYP19A1 genetic variation in relation to prostate cancer risk and circulating sex hormone concentrations in men from the Breast and Prostate Cancer Cohort Consortium
dc.typeJournal Article
dc.description.versionAccepted Manuscript
dc.relation.journalCancer Epidemiology, Biomarkers & Prevention
dash.depositing.authorStampfer, Meir
dc.date.available2019-09-06T14:15:26Z
dash.workflow.comments1Science Serial ID 26440
dc.identifier.doi10.1158/1055-9965.EPI-09-0496
dash.source.volume18;10
dash.source.page2734
dash.contributor.affiliatedStampfer, Meir


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